Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis
Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis
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DOI：
10.1161/01.atv.0000190660.32863.cd
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发表时间：
2005-12-01
影响因子：
8.7
通讯作者：
Nishizawa, Y
中科院分区：
文献类型：
--
作者：
Koyama, H;Shoji, T;Nishizawa, Y
目的：晚期糖基化终产物（AGEs）及其特异性受体（AGEs）参与糖尿病血管并发症的发生.内源性分泌型β-内酰胺酶（esophagus）被鉴定为β-内酰胺酶的一种选择性剪接形式，并被证明是AGE的诱饵受体。在这里，我们测量血浆内皮素水平与最近开发的酶联免疫吸附试验（ELISA），并研究其与动脉粥样硬化的年龄和性别匹配的203型2型糖尿病和134 nondiabetic subjects.Methods和结果-血浆内皮素与颈动脉或股动脉粥样硬化呈负相关，作为定量测量的内膜中层厚度（IMT）动脉超声。逐步回归分析显示，血浆雌二醇是与颈动脉IMT相关的第三强和独立因素，仅次于年龄和收缩压。糖尿病患者的血浆雌二醇水平（0.176 +/- 0.092 ng/mL）显著低于非糖尿病对照组（0.253 +/- 0.111 ng/mL）。值得注意的是，在所有糖尿病或非糖尿病组中，血浆雌二醇与代谢综合征的组分（包括体重指数、血压、甘油三酯、HbA 1c或胰岛素抵抗指数）显著负相关。逐步回归分析显示，在所有人群、非糖尿病人群和糖尿病人群中，体重指数或胰岛素抵抗指数是影响血浆雌二醇水平的主要因素。结论雌二醇是代谢综合征和动脉粥样硬化的一个新的潜在保护因子。
Objectives - Advanced glycation endproducts, AGEs, and its specific receptor, RAGE, are involved in diabetic vascular complications. Endogenous secretory RAGE, esRAGE, has been identified as an alternatively spliced form of RAGE, and shown to act as a decoy receptor for AGE. Here, we measured plasma esRAGE level with a recently developed enzyme-linked immunosorbent assay ( ELISA) and examined its association with atherosclerosis in age- and gender-matched 203 type 2 diabetic and 134 nondiabetic subjects.Methods and Results - Plasma esRAGE was inversely associated with carotid or femoral atherosclerosis, as quantitatively measured as intimal-medial thickness (IMT) by arterial ultrasound. Stepwise regression analyses revealed that plasma esRAGE was the third strongest and independent factor associated with carotid IMT, following age and systolic blood pressure. Plasma esRAGE was significantly lower in diabetic patients (0.176 +/- 0.092 ng/mL) than nondiabetic controls (0.253 +/- 0.111). Of note, in all, diabetic or nondiabetic group, plasma esRAGE was significantly and inversely correlated with components of the metabolic syndrome including body mass index, blood pressure, triglyceride, HbA1c, or an insulin resistance index. Stepwise regression analyses showed that body mass index or insulin resistance index was the major factor determining plasma esRAGE in all, nondiabetic or diabetic population.Conclusions - esRAGE is a novel and potential protective factor for the metabolic syndrome and atherosclerosis.