Ciclopirox olamine 1% cream. A preliminary review of its antimicrobial activity and therapeutic use.
Ciclopirox olamine 1% cream. A preliminary review of its antimicrobial activity and therapeutic use.
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DOI：
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发表时间：
1985
期刊：
影响因子：
11.5
通讯作者：
S. Jue;G. Dawson;R. N. Brogden
中科院分区：
文献类型：
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作者：
S. Jue;G. Dawson;R. N. Brogden
环吡酮胺是一种取代的吡啶酮抗真菌药，与咪唑衍生物无关，对广谱皮肤癣菌、酵母菌、放线菌、霉菌、其他真菌以及多种革兰氏阳性和革兰氏阴性细菌具有活性。环吡酮胺乳膏的疗效已在浅表皮肤真菌或酵母菌感染患者的开放和安慰剂对照研究中得到证实，在皮肤真菌病患者的双盲比较试验中，局部环吡酮胺在疗效上与克霉唑相当或优于克霉唑，并引起类似数量的副作用。环吡酮胺可透过指甲，在初步研究中已成功用于甲真菌病。然而，需要进一步的研究来确定环吡酮相对于最近引入的抗真菌剂在治疗甲真菌病和皮肤真菌病中的作用。
Ciclopirox olamine is a substituted pyridone antimycotic, unrelated to the imidazole derivatives, with activity against a broad spectrum of dermatophytes, yeasts, actinomycetes, molds, other fungi, and a variety of Gram-positive and Gram-negative bacteria. The efficacy of ciclopirox olamine cream has been demonstrated in open and placebo-controlled studies in patients with superficial dermatophyte or yeast infections, and in double-blind comparative trials in patients with dermatomycoses, topical ciclopirox olamine was comparable to or better than clotrimazole in efficacy and caused a similar number of side effects. Ciclopirox olamine penetrates through fingernails and in preliminary studies has been successfully used in onychomycoses. However, further studies are needed to establish the role of ciclopirox in the treatment of onychomycoses and dermatomycoses relative to that of the more recently introduced antigungal agents.