A light and electron microscopic analysis of gentamicin nephrotoxicity in rats.
A light and electron microscopic analysis of gentamicin nephrotoxicity in rats.
复制标题
庆大霉素对大鼠肾毒性的光镜和电镜分析。
DOI：
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发表时间：
1976
影响因子：
6
通讯作者：
W. Bennett
中科院分区：
文献类型：
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作者：
D. Houghton;M. Hartnett;M. Campbell;G. Porter;W. Bennett
用光镜和电镜观察了硫酸庆大霉素对Fischer 344大鼠近端肾小管损伤和修复的影响。该药物以40 mg/kg的剂量给药，最长14天。虽然上皮细胞的破坏是随着时间的推移而进行性的，但在每个时间间隔，小管损伤的程度和程度在动物之间是不同的。尽管继续给药，小管再生在第10天开始发生。再生细胞似乎起源于小管损伤区残留的上皮细胞。形态上不成熟的再生细胞显然在代谢上也不成熟，似乎对药物的毒性作用不敏感。庆大霉素停用后3天重新填充小管。在31天结束时，除了小管萎缩和间质纤维化的病灶外，皮质组织的超微结构与对照组相当。
The sequence of proximal tubular damage and repair after gentamicin sulfate administration was studied by light and electron microscopy in Fischer 344 rats. The drug was administered at a dose of 40 mg/kg for up to 14 days. Although epithelial destruction was progressive with time, the extent and degree of tubular damage varied among animals at each interval. Tubule regeneration began to occur by the tenth day despite continued drug administration. Regenerating cells appeared to originate from residual epithelial cells in areas of tubular damage. The morphologically immature regenerating cells are apparently metabolically immature as well and appear not to be susceptible to toxic effects of the drug. Tubules were repopulated by 3 days following cessation of gentamicin administration. Except for foci of tubular atrophy and interstitial fibrosis, cortical tissues were comparable to controls ultrastructurally at the end of 31 days.