MU-OPIOID AND DELTA-OPIOID RECEPTORS CONTROL DIFFERENTLY THE HORIZONTAL AND VERTICAL COMPONENTS OF LOCOMOTOR-ACTIVITY IN MICE
MU-OPIOID AND DELTA-OPIOID RECEPTORS CONTROL DIFFERENTLY THE HORIZONTAL AND VERTICAL COMPONENTS OF LOCOMOTOR-ACTIVITY IN MICE
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DOI：
10.1016/0143-4179(89)90076-0
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发表时间：
1989-05-01
期刊：
影响因子：
2.9
通讯作者：
COSTENTIN, J
中科院分区：
文献类型：
--
作者：
MICHAELTITUS, A;DOURMAP, N;COSTENTIN, J
本研究探讨了mu和delta阿片受体在控制运动的水平和垂直成分中的作用。小鼠接受脑室内（I.C.V.）脑啡肽类似物特异性的mu或delta阿片受体。给药特异性受体激动剂[D-Ala2-NMePHe4-Gly5(ol)]脑啡碱（DAGO）诱导水平活性呈剂量依赖性增加，垂直活性降低。特异性的δ受体激动剂[D-Pen2， D-Pen5] enkepalin （DPDPE）增加了这两种成分的运动活性。阿片拮抗剂纳曲酮逆转了DAGO的作用，但对DPDPE对运动活动的影响没有影响。阿片剂ICI 154, 129预处理完全逆转DPDPE对运动的影响，但仅部分拮抗DAGO对运动的影响。这些结果表明，运动活动的两个组成部分-水平活动和垂直活动-受到刺激的mu或delta阿片受体的不同调节。
The present study investigated the role of mu and delta opioid receptors in the control of the horizontal and vertical components of locomation. Mice received intracerebroventricularly (I.C.V.) enkephalin analogs specific for either the mu or delta opioid receptors. The administration of the specific mu agonist [D-Ala2-NMePHe4-Gly5(ol)] enkephaline (DAGO) induced a dose-dependent increase in horizontal activity and a decrease in vertical activity. The specific delta agonist [D-Pen2, D-Pen5] enkepalin (DPDPE) increased both components of motor activity. The opiate antagonist naltrexone reversed the effects of DAGO, but did to influence the effects of DPDPE on motor activity. The pretreatment with the delta opiate antagonist ICI 154, 129 completely reversed the effects of DPDPE on locomotion but antagonized only partially the effects of DAGO on locomotion. These results indicate that the two components of locomoter activity- horizontal and vertical activity - are modulated differently by the stimulation of mu or delta opioid receptors.