Associations Between Dietary Melatonin Intake and Total and Cause-Specific Mortality Among Japanese Adults in the Takayama Study
Associations Between Dietary Melatonin Intake and Total and Cause-Specific Mortality Among Japanese Adults in the Takayama Study
复制标题
高山研究中膳食褪黑素摄入量与日本成年人总死亡率和特定原因死亡率之间的关联
DOI：
10.1093/aje/kwab213
复制
发表时间：
2021
影响因子：
5
通讯作者：
Hattori Atsuhiko
中科院分区：
文献类型：
--
作者：
Nagata Chisato;Wada Keiko;Yamakawa Michiyo;Nakashima Yuma;Koda Sachi;Uji Takahiro;Onuma Sakiko;Oba Shino;Maruyama Yusuke;Hattori Atsuhiko
褪黑激素的潜在健康益处已经被提出。虽然褪黑激素存在于各种食物中，但对饮食褪黑激素摄入量的健康影响知之甚少。我们在日本进行的一项基于人群的队列研究中估计了习惯性饮食褪黑激素摄入量，并研究了其与总死亡率和死因特异性死亡率的关系。研究受试者包括年龄≥35岁的13，355名男性和15，724名女性，他们在1992年回答了自填问卷。他们的饮食通过基线时的食物频率问卷进行评估。测量问卷上各种食物中褪黑激素的含量来估计褪黑激素的摄入量。在16年的随访期间（1992-2008年）确定了死亡率。根据褪黑激素四分位数计算总死亡率和死因特异性死亡率的风险比（HR）和95%置信区间（CI）。随访期间共有5，339人死亡。在控制协变量后，褪黑激素摄入量与总死亡率、心血管死亡率和非癌症、非心血管死亡率的风险降低显著相关;褪黑激素摄入量最高四分位数与最低四分位数的HR为0.90（95% CI：0.82，0.98;趋势P = 0.05）、0.85（95% CI：0.72，0.99;趋势P = 0.10）和0.77（95% CI：0.67，0.90;趋势P = 0.003）。这些数据表明，饮食褪黑激素对死亡率有潜在的好处。
Potential health benefits of melatonin have been suggested. Although melatonin is present in various foods, little is known about the health effects of dietary melatonin intake. We estimated habitual dietary melatonin intake and examined its association with total and cause-specific mortality in a population-based cohort study in Japan. Study subjects included 13,355 men and 15,724 women aged ≥35 years who responded to a self-administered questionnaire in 1992. Their diets were assessed via a food frequency questionnaire at baseline. The melatonin content in various foods on the questionnaire was measured to estimate melatonin intake. Mortality was ascertained during 16 years of follow-up (1992–2008). Hazard ratios (HRs) and 95% confidence intervals (CIs) for total and cause-specific mortality were calculated according to melatonin quartiles. A total of 5,339 deaths occurred during follow-up. Melatonin intake was significantly associated with decreased risks of total mortality, cardiovascular mortality, and noncancer, noncardiovascular mortality after controlling for covariates; HRs for the highest quartile of melatonin intake versus the lowest were 0.90 (95% CI: 0.82, 0.98;Pfor trend = 0.05), 0.85 (95% CI: 0.72, 0.99;Pfor trend = 0.10), and 0.77 (95% CI: 0.67, 0.90;Pfor trend = 0.003), respectively. The data suggest a potential benefit of dietary melatonin with regard to mortality rates.