Mapping of psoriasis to 17q terminus
Mapping of psoriasis to 17q terminus
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DOI：
10.1136/jmg.2004.018564
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发表时间：
2005-02-01
影响因子：
4
通讯作者：
Chen, YT
中科院分区：
文献类型：
--
作者：
Hwu, WL;Yang, CF;Chen, YT
一个五代的银屑病家族，具有明显的常染色体显性遗传（图1），在国立台湾大学医院被确定。所有人都由至少两名皮肤科医生进行检查。该家族共有93名成员，其中16名患有银屑病的典型皮肤表现，10名患有轻度皮肤病变，43名未受影响（图2）。由于银屑病表达的年龄依赖性变化，24名年龄小于30岁、外观正常的家庭成员被归类为“未知疾病”。该研究获得了国立台湾大学医院机构审查委员会的批准。从每名参与者处获得知情同意书。
METHODS Family ascertainment A five generation psoriasis kindred with apparent autosomal dominant inheritance (fig 1) was identified at the NationalTaiwan University Hospital. All individuals were examined by at least two dermatologists. This family comprised a total of 93 members, including 16 with classical skin manifestations of psoriasis, 10 with mild skin lesions, and 43 who were unaffected (fig 2). Because of age dependent variation in the expression of psoriasis, 24 family members aged less than 30 who presented with a normal appearance received the ‘‘unknown disease’’classification. The study was approved by the institutional review board at the National Taiwan University Hospital. Informed consent was obtained from each participating person.