Retinal oximetry in humans using visible-light optical coherence tomography [Invited]
Retinal oximetry in humans using visible-light optical coherence tomography [Invited]
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DOI：
10.1364/boe.8.001415
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发表时间：
2017-03-01
影响因子：
3.4
通讯作者：
Zhang, Hao F.
中科院分区：
文献类型：
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作者：
Chen, Siyu;Shu, Xiao;Zhang, Hao F.
我们使用可见光光学相干断层扫描(VIS-OCT)测量了健康人视网膜循环中的血红蛋白血氧饱和度(SO2)。测量结果显示，靠近视神经头的视网膜中央动脉和静脉之间的氧合作用存在明显差异。在不同的维管分枝水平上也显示出空间差异。此外，我们还给出了理论和实验结果，以确定OCT强度中的噪声服从大米分布。我们使用这些信息来恢复真实OCT强度的无偏估计，以提高VIS-OCT血氧仪的准确性，由于安全性和舒适性的限制，VIS-OCT血氧仪天生具有较低的人眼信噪比。我们证明，新的统计拟合抽样策略可以将SO(2)的估计误差减少3个百分点(Pp)。本工作旨在为在临床环境中使用VIS-OCT实现准确的视网膜血氧饱和度测量提供基础。(C)2017年美国光学学会
We measured hemoglobin oxygen saturation (sO(2)) in the retinal circulation in healthy humans using visible-light optical coherence tomography (vis-OCT). The measurements showed clear oxygenation differences between central retinal arteries and veins close to the optic nerve head. Spatial variations at different vascular branching levels were also revealed. In addition, we presented theoretical and experimental results to establish that noises in OCT intensity followed Rice distribution. We used this knowledge to retrieve unbiased estimation of true OCT intensity to improve the accuracy of vis-OCT oximetry, which had inherently lower signal-to-nose ratio from human eyes due to safety and comfort limitations. We demonstrated that the new statistical-fitting sampling strategy could reduce the estimation error in sO(2) by three percentage points (pp). The presented work aims to provide a foundation for using vis-OCT to achieve accurate retinal oximetry in clinical settings. (C) 2017 Optical Society of America