DIVERSE FORMS OF A RECEPTOR FOR ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS
DIVERSE FORMS OF A RECEPTOR FOR ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS
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DOI：
10.1128/mcb.10.9.4728
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发表时间：
1990-09-01
影响因子：
5.3
通讯作者：
WILLIAMS, LT
中科院分区：
文献类型：
--
作者：
JOHNSON, DE;LEE, PL;WILLIAMS, LT
我们最近报道了分离的鸡cDNA克隆编码碱性成纤维细胞生长因子（FGF）受体，有三个免疫球蛋白样结构域的细胞外区域。我们现在已经确定了四个独特的人类cDNA克隆编码以前未知的FGF受体变体，其中只含有两个免疫球蛋白样结构域。两个人类克隆编码跨膜受体，两个编码推定的分泌形式。这两个三个和两个免疫球蛋白样结构域形式介导的生物反应，酸性和碱性FGF。因此，三结构域形式的第一免疫球蛋白样结构域可以具有除结合酸性和碱性FGF之外的功能。
We recently reported the isolation of a chicken cDNA clone encoding a basic fibroblast growth factor (FGF) receptor that has three immunoglobulinlike domains in the extracellular region. We have now identified four unique human cDNA clones encoding previously unknown FGF receptor variants which contain only two immunoglobulinlike domains. Two of the human clones encode membrane-spanning receptors, and two encode putative secreted forms. Both the three- and two-immunoglobulinlike-domain forms mediate biological responsiveness to acidic and basic FGF. Thus, the first immunoglobulinlike domain of the three-domain form may have a function other than binding of acidic and basic FGF.