Cardiovascular health and cognitive outcomes: Findings from a biracial population-based study in the United States.
Cardiovascular health and cognitive outcomes: Findings from a biracial population-based study in the United States.
复制标题
心血管健康和认知结果：美国一项基于混血人口的研究的结果。
DOI：
10.1002/alz.13421
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Rajan,KumarB
中科院分区：
文献类型：
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作者：
Dhana,Anisa;DeCarli,CharlesS;Dhana,Klodian;Desai,Pankaja;Holland,ThomasM;Evans,DenisA;Rajan,KumarB
INTRODUCTIONThe aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure.METHODSThis study consisted of 1702 Black or African American and White participants living in the south side of Chicago, Illinois, and enrolled in the Chicago Health and Aging Project, a population‐based cohort since 1993. CVH was based on seven risk factors, including diet, physical activity, body mass index, smoking, dyslipidemia, hypertension, and diabetes.RESULTSIn a multivariable‐adjusted model, CVH was associated with a lower risk of Alzheimer's dementia. The hazard ratio per 1 additional point in CVH score was 0.84 (95% CI 0.76, 0.94). CVH was also associated with a slower rate of cognitive decline and less volume (injury) in white matter hyperintensities.DISCUSSIONPromoting CVH in communities with Black residents may lower the future risk of Alzheimer's dementia.
