FAMILY CONCORDANCE OF IGE, ATOPY, AND DISEASE
FAMILY CONCORDANCE OF IGE, ATOPY, AND DISEASE
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DOI：
10.1016/s0091-6749(84)80017-2
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发表时间：
1984-01-01
影响因子：
14.2
通讯作者：
BURROWS, B
中科院分区：
文献类型：
--
作者：
LEBOWITZ, MD;BARBEE, R;BURROWS, B
对美国亚利桑那州图森地区社区白人家庭344个核心家庭进行了IgE家族一致性研究。在控制年龄、性别、吸烟状况和皮肤试验反应性后，使用多因素方差分析显示，总循环IgE具有显著的家族一致性。这种关系在兄弟姐妹中最为明显，在父母和子女之间也很明显，而在配偶之间则不存在。皮肤试验反应性用相同的统计方法显示独立的家族一致性。报告的哮喘、喘息和过敏性鼻炎病史的诊断也显示出家庭患病率的强烈一致性。
Family concordance of IgE was determined in 344 nuclear families that were studied in a community population of white families in the Tucson [Arizona, USA] area. Total circulating IgE, after controlling for age, sex, smoking status and skin test reactivity demonstrated a significant family concordance with the use of multifactional analysis of variance. This relationship was strongest among siblings, was significant as well between parents and children, and was not present between spouses. Skin test reactivity demonstrated independent family concordance with the same statistical methods. Reported diagnoses of asthma, wheeze and allergic-rhinitis histories demonstrated a strong concordance of prevalence rates in families as well.