DEPRESSED CARDIAC SARCOPLASMIC RETICULAR FUNCTION FROM DIABETIC RATS
DEPRESSED CARDIAC SARCOPLASMIC RETICULAR FUNCTION FROM DIABETIC RATS
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DOI：
10.1016/0022-2828(81)90318-7
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发表时间：
1981-01-01
影响因子：
5
通讯作者：
SCHEUER, J
中科院分区：
文献类型：
--
作者：
PENPARGKUL, S;FEIN, F;SCHEUER, J
先前的研究表明，糖尿病大鼠的心脏收缩功能受损和松弛延迟。用链脲佐菌素诱导雄性和雌性大鼠患上糖尿病，4 ~ 5周和9周后观察心脏变化。女性糖尿病患者的血糖平均为453 mg/100 ml，男性糖尿病患者的血糖平均为615 mg/100 ml。在不含草酸盐的情况下，糖尿病男性和女性心脏制剂中肌浆网（SR）对Ca的摄取明显低于对照组。链脲佐菌素前用3- o -甲基葡萄糖预处理的大鼠，在草酸缺乏的情况下，SR与Ca的结合正常。糖尿病动物制剂显著降低SR Mg2+ atp酶和Ca2+-Mg2+（总）atp酶活性。该结果可以部分解释先前在糖尿病动物心脏中观察到的收缩和舒张异常。
Previous studies demonstrated impaired contractile performance and delayed relaxation of hearts of diabetic rats. Male and female rats were made diabetic with i.v. streptozotocin and their hearts were studied 4-5 or 9 wk later. Plasma glucose in female diabetics averaged 453 mg/100 ml and in male diabetics 615 mg/100 ml. Ca uptake by isolated sarcoplasmic reticulum (SR) in the absence of oxalate were significantly lower in preparations from hearts of diabetic males and females than from controls. Rats pretreated with 3-O-methyl glucose before streptozotocin had normal Ca binding by SR in the absence of oxalate. SR Mg2+ ATPase and Ca2+-Mg2+ (total) ATPase activities were significantly depressed in preparations from the diabetic animals. The results may partially explain the abnormalities in contraction and relaxation previously observed in hearts of diabetic animals.