The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin
The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin
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DOI：
10.1309/ajcpww2urz9jkqju
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发表时间：
2014-05-01
影响因子：
3.5
通讯作者：
Ponten, Fredrik
中科院分区：
文献类型：
--
作者：
Dragomir, Anca;de Wit, Meike;Ponten, Fredrik
目的：免疫组织化学是临床信息和形态学的重要延伸，并且作为在临床诊断病理学中建立正确的癌症诊断的宝贵工具而流行。免疫组织化学的适用性受到经验证的细胞和癌症类型特异性抗体的可用性的限制，使得发现、测试和验证新标记物的需求未得到满足。SATB 2蛋白选择性表达于下消化道腺细胞，并且在绝大多数原发性和转移性结直肠癌中仍有表达。方法：我们分析了所有临床病例（n = 840）中SATB 2的表达，其中，免疫组化检测CK 20被认为是最终诊断所必需的。结论：SATB 2对大肠癌的诊断具有较高的敏感性（93%）和特异性（77%），与CK7和CK20联合应用，其特异性可达100%。
Objectives: Immunohistochemistry is an important extension to clinical information and morphology, and prevails as an invaluable tool for establishing a correct cancer diagnosis in clinical diagnostic pathology. The applicability of immunohistochemistry is limited by the availability of validated cell- and cancer-type specific antibodies, rendering an unmet need to discover, test, and validate novel markers. The SATB2 protein is selectively expressed in glandular cells from the lower gastrointestinal tract and expression is retained in a large majority of primary and metastatic colorectal cancers.Methods: We analyzed the expression of SATB2 in all clinical cases (n = 840), in which immunohistochemistry for detection of CK20 was deemed necessary for a final diagnosis.Results: SATB2 showed a high sensitivity (93%) and specificity (77%) to determine a cancer of colorectal origin and in combination with CK7 and CK20, the specificity increased to 100%.Conclusions: We conclude that SATB2 provides a new and advantageous supplement for clinical differential diagnostics.