Behavioral/systems/cognitive Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
Behavioral/systems/cognitive Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
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通讯作者：
F. Champagne;P. Chrétien;C. Stevenson;Yuan Zhang;A. Gratton;M. Meaney
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作者：
F. Champagne;P. Chrétien;C. Stevenson;Yuan Zhang;A. Gratton;M. Meaney
哺乳期大鼠在幼崽舔/理毛方面表现出稳定的个体差异。我们使用体内伏安法来监测丘脑核中细胞外多巴胺（DA）的变化。Acc）壳与幼鼠互动，发现（1）DA信号随幼鼠舔/理毛显著增加;（2）这种增加的开始先于幼鼠舔/理毛;（3）DA信号增加的幅度和持续时间与舔/理毛回合的持续时间显著相关。在女性特征的基础上的行为观察高舔/梳理母亲，DA信号与舔/梳理的增加幅度显着大于低舔/梳理的大坝。多巴胺转运蛋白结合。与高舔/梳理母亲相比，低舔/梳理母亲的ACC增加。注射选择性DA摄取抑制剂GBR 12909 [1-（2-（双-（4-氟苯基）甲氧基）乙基）-4-（3-苯基丙基）哌嗪二盐酸盐]（5 mg/kg，s.c.）增加了n.低舔/理毛母鼠的ACC和幼仔舔/理毛水平与高舔/理毛母鼠中观察到的水平相当。受体放射自显影研究表明，在n.高舔/梳理母鼠的ACC壳区。这些结果表明，高和低舔/梳理大坝不同的中脑边缘多巴胺能活性与母犬的相互作用。这种差异可能作为神经基板的个体差异的动机组成部分的母亲的行为。
Lactating rats exhibit stable individual differences in pup licking/grooming. We used in vivo voltammetry to monitor changes in extra-cellular dopamine (DA) in the nucleus accumbens (n. Acc) shell of lactating rats interacting with pups and found that (1) the DA signal increased significantly with pup licking/grooming; (2) the onset of such increases preceded pup licking/grooming; and (3) the magnitude and duration of the increase in the DA signal were significantly correlated with the duration of the licking/grooming bout. In females characterized on the basis of behavioral observations as high-licking/grooming mothers, the magnitude of the increase in the DA signal associated with licking/grooming was significantly greater than in low-licking/grooming dams. Dopamine transporter binding in the n. Acc was increased in low-compared with high-licking/grooming mothers. Injection of the selective DA uptake inhibitor GBR 12909 [1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3 phenypropyl)piperazine dihydrochloride] (5 mg/kg, s.c.) increased the DA signal in the n. Acc and pup licking/grooming in low-licking/grooming mothers to levels comparable with those observed in high-licking/grooming dams. Receptor autoradiographic studies showed elevated levels of D 1 and D 3 receptors in the n. Acc shell region in high-licking/ grooming dams. These results suggest that high-and low-licking/grooming dams differ in mesolimbic dopaminergic activity associated with mother–pup interactions. Such differences may serve as neural substrates for individual differences in the motivational component of maternal behavior.