A new member of the frizzled family from Drosophila functions as a Wingless receptor
A new member of the frizzled family from Drosophila functions as a Wingless receptor
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DOI：
10.1038/382225a0
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发表时间：
1996-07-18
期刊：
影响因子：
64.8
通讯作者：
Nusse, R
中科院分区：
文献类型：
--
作者：
Bhanot, P;Brink, M;Nusse, R
Wnt基因家族的无翼和其他信号分子的受体尚未确定。我们在这里显示，在培养的果蝇细胞中，通过提高Armadillo蛋白的水平来响应加入Wingless蛋白的果蝇细胞，该基因家族中的一个新成员Dfz2。此外，Wingless与表达Dfz2的果蝇或人类细胞结合。这些数据表明，Dfz2作为一种无翼受体发挥作用，它们通常意味着Frizzled蛋白质是Wnt信号分子的受体。
Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.