Involvement of an Essential Gene, mviN, in Murein Synthesis in Escherichia coli
Involvement of an Essential Gene, mviN, in Murein Synthesis in Escherichia coli
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DOI：
10.1128/jb.00551-08
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发表时间：
2008-11-01
影响因子：
3.2
通讯作者：
Kato, Jun-ichi
中科院分区：
文献类型：
--
作者：
Inoue, Azusa;Murata, Yoshimitsu;Kato, Jun-ichi
我们分离了一个温度敏感的突变体，突变的mviN，在大肠杆菌的必需基因。在非允许的温度下，mviN突变体细胞肿胀并破裂。胞壁素合成的中间体，聚异戊二烯二磷酸-N-乙酰胞壁酸-（五肽）-N-乙酰葡糖胺，在突变细胞中积累。这些结果表明MviN参与胞壁素的合成。
We isolated a temperature-sensitive mutant with a mutation in mviN, an essential gene in Escherichia coli. At the nonpermissive temperature, mviN mutant cells swelled and burst. An intermediate in murein synthesis, polyprenyl diphosphate-N-acetylmuramic acid-(pentapeptide)-N-acetyl-glucosamine, accumulated in mutant cells. These results indicated that MviN is involved in murein synthesis.