Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
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DOI：
10.1093/ajcn/86.2.324
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发表时间：
2007-08-01
影响因子：
7.1
通讯作者：
Mackey, Bruce E.
中科院分区：
文献类型：
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作者：
Kelley, Darshan S.;Siegel, David;Mackey, Bruce E.
背景：二十二碳六烯酸（DHA）对VLDL、LDL和HDL亚类的平均大小和浓度的影响尚未被研究过。目的：研究补充DHA对载脂蛋白浓度的影响；大、中、小VLDL、LDL、HDL颗粒；以及空腹和餐后血浆中这些颗粒的平均直径。设计：39-66岁的高甘油三酯血症男性（n = 34）参加了一项双盲、随机、安慰剂对照的平行研究。他们在前8天没有服用任何补充剂，在最后90天服用7.5 g DHA油（3 g DHA/d）或橄榄油（安慰剂）。通过核磁共振波谱法测量脂蛋白颗粒直径和浓度。结果：DHA添加45 d显著（P < 0.05）降低了空腹甘油三酯（24%）、大VLDL（92%）和中密度脂蛋白（53%）的浓度，降低了VLDL颗粒的平均直径（11%）。1海里)。它使空腹血浆中LDL胆固醇（12.6%）、小VLDL颗粒（133%）和大LDL颗粒（120%）浓度升高，LDL颗粒平均直径（0.6 nm）升高。在餐后样品（0 -6 h）曲线下的面积也观察到类似的变化；然而，小密度LDL颗粒数量明显减少（21%），LDL胆固醇变化不显著。继续补充DHA超过45天没有进一步的变化；安慰剂治疗没有改变测试中的任何反应。结论：补充DHA可通过降低甘油三酯和sma致密LDL颗粒浓度来改善心血管健康。
Background: The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.Objective: We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.Design: Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.Results: DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11. 1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0 -6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.Conclusion: DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and sma dense LDL particles.