Tractography of supplementary motor area projections in progressive speech apraxia and aphasia.
Tractography of supplementary motor area projections in progressive speech apraxia and aphasia.
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DOI：
10.1016/j.nicl.2022.102999
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Whitwell JL
中科院分区：
文献类型：
--
作者：
Valls Carbo A;Reid RI;Tosakulwong N;Weigand SD;Duffy JR;Clark HM;Utianski RL;Botha H;Machulda MM;Strand EA;Schwarz CG;Jack CR;Josephs KA;Whitwell JL
SMA白色物质束的变性发生在进行性言语失用症中。SMA连合、壳核和中央前束与言语失用症相关。语法缺失与SMA-前额叶和额叶倾斜束相关。道谱分析表明，不同的疾病震中综合征。进行性言语失用症（AOS）是一种运动性言语障碍，影响语音或韵律正常言语的能力。进行性AOS可以单独出现，也可以与语法缺失性失语同时出现，并与辅助运动区的退化有关。我们旨在评估进行性AOS和/或语法缺失性失语患者的辅助运动区结构连接的破坏，以确定哪些辅助运动区束与这些临床症状具体相关。神经退行性疾病研究组招募了84例进行性AOS或进行性失语症患者，并进行了神经学、言语/语言和神经心理学测试以及3 T弥散磁共振成像。在84例患者中，36例为孤立性言语失用症（原发性进行性言语失用症，PPAOS），40例为言语失用症和语法性失语症（AOS-PAA），8例为孤立性语法性失语症（进行性语法性失语症，PAA）。进行纤维束造影，以确定5个不同的管道连接到辅助运动区。在沿着管道长度的10个位置沿着评估各向异性分数和平均扩散率，以构建管道剖面，并计算每个管道的中位数剖面。在病例对照比较中，与对照组相比，在所有三组中沿着补充运动区连合纤维观察到各向异性分数降低和平均扩散率增加。PPAOS还在从辅助运动区到壳核、前额叶皮质、布罗卡区（额叶斜束）和运动皮质的束中存在异常扩散，最接近辅助运动区观察到最大的异常。AOS-PAA组在同一组束中显示出异常，但与PPAOS相比，前额叶束的补充运动区的参与程度更高。与其他两组相比，PAA显示左前额叶和额叶倾斜束异常，PAA显示最大的异常最远的辅助运动区。AOS的严重程度与补充运动区连合和运动皮质束的束指标相关。失语症的严重程度与额斜束和额前束有关。这些研究结果提供了深入了解AOS和语法缺失是如何差异相关的干扰扩散，与进行性AOS与异常接近的辅助运动区，和额叶倾斜和前额叶束特别与语法缺失性失语症。
Degeneration of SMA white matter tracts occurs in progressive apraxia of speech. SMA commissural, putamen and precentral tracts were associated with speech apraxia. Agrammatism was associated with SMA-prefrontal and frontal aslant tracts. Tract profile analysis suggests different disease epicenters across syndromes. Progressive apraxia of speech (AOS) is a motor speech disorder affecting the ability to produce phonetically or prosodically normal speech. Progressive AOS can present in isolation or co-occur with agrammatic aphasia and is associated with degeneration of the supplementary motor area. We aimed to assess breakdowns in structural connectivity from the supplementary motor area in patients with any combination of progressive AOS and/or agrammatic aphasia to determine which supplementary motor area tracts are specifically related to these clinical symptoms. Eighty-four patients with progressive AOS or progressive agrammatic aphasia were recruited by the Neurodegenerative Research Group and underwent neurological, speech/language, and neuropsychological testing, as well as 3 T diffusion magnetic resonance imaging. Of the 84 patients, 36 had apraxia of speech in isolation (primary progressive apraxia of speech, PPAOS), 40 had apraxia of speech and agrammatic aphasia (AOS-PAA), and eight had agrammatic aphasia in isolation (progressive agrammatic aphasia, PAA). Tractography was performed to identify 5 distinct tracts connecting to the supplementary motor area. Fractional anisotropy and mean diffusivity were assessed at 10 positions along the length of the tracts to construct tract profiles, and median profiles were calculated for each tract. In a case-control comparison, decreased fractional anisotropy and increased mean diffusivity were observed along the supplementary motor area commissural fibers in all three groups compared to controls. PPAOS also had abnormal diffusion in tracts from the supplementary motor area to the putamen, prefrontal cortex, Broca’s area (frontal aslant tract) and motor cortex, with greatest abnormalities observed closest to the supplementary motor area. The AOS-PAA group showed abnormalities in the same set of tracts, but with greater involvement of the supplementary motor area to prefrontal tract compared to PPAOS. PAA showed abnormalities in the left prefrontal and frontal aslant tracts compared to both other groups, with PAA showing greatest abnormalities furthest from the supplementary motor area. Severity of AOS correlated with tract metrics in the supplementary motor area commissural and motor cortex tracts. Severity of aphasia correlated with the frontal aslant and prefrontal tracts. These findings provide insight into how AOS and agrammatism are differentially related to disrupted diffusivity, with progressive AOS associated with abnormalities close to the supplementary motor area, and the frontal aslant and prefrontal tracts being particularly associated with agrammatic aphasia.
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影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
4.2
作者：
Botha, Hugo;Utianski, Rene L.;Jones, David T.
通讯作者：
Jones, David T.
影响因子：
14.5
作者：
DERENZI, E;VIGNOLO, LA
通讯作者：
VIGNOLO, LA
DOI：
10.1044/1092-4388(2012/11-0323
发表时间：
2012-10-01
影响因子：
2.6
作者：
Croot, Karen;Ballard, Kirrie;Hodges, John R.
通讯作者：
Hodges, John R.
影响因子：
2
作者：
Duffy, Joseph R.
通讯作者：
Duffy, Joseph R.