Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.
Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.
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DOI：
10.3945/jn.108.094268
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
J. Whelan
中科院分区：
文献类型：
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作者：
J. Whelan
来自鱼类的（n-3）长链PUFA （LCPUFA）的治疗和促进健康的作用是众所周知的，尽管它们的前体α -亚麻酸（ALA）可能没有同样的好处。世界范围内的机构和科学组织（如FDA， AHA，国际脂肪酸和脂质研究学会，医学研究所，WHO等）也对（n-3） LCPUFA提出了类似的饮食建议；然而，由于担心食用鱼类的安全性，正在调查（n-3） LCPUFA的替代来源。其中一种脂质是硬脂酸（SDA），一种天然存在的（n-3） PUFA，可能与鱼油中主要的（n-3） PUFA二十碳五烯酸（EPA）具有相似的生物学特性。现有的和新的富含SDA的植物来源正在被培育和推广，作为海洋（n-3）多聚脂肪酸的潜在替代品。在类似的实验条件下，本综述对SDA与其他饲粮（n-3） PUFA进行了直接比较。比较结果表明，在典型的西方饮食中，与ALA相比，SDA具有（n-3） LCPUFA的许多生物学效应，其功能与膳食EPA最相似。因此，尽管SDA可能不会取代鱼类作为（n-3） LCPUFA的主要膳食来源，但它可能在（n-3） PUFA强化食品的商业开发中成为EPA的重要替代品。
The therapeutic and health-promoting effects of (n-3) long-chain PUFA (LCPUFA) from fish are well known, although these same benefits may not be shared by their precursor, alpha-linolenic acid (ALA). World-wide agencies and scientific organizations (i.e. FDA, AHA, International Society for the Study of Fatty Acids and Lipids, Institute of Medicine, WHO, etc.) have made similar dietary recommendations for (n-3) LCPUFA; however, due to concerns regarding the safety of consuming fish, alternative sources of (n-3) LCPUFA are being investigated. One such lipid is stearidonic acid (SDA), a naturally occurring (n-3) PUFA that may have similar biological properties to eicosapentaenoic acid (EPA), a major (n-3) PUFA in fish oil. Existing and novel plant sources rich in SDA are being cultivated and promoted as potential alternatives to marine-based (n-3) PUFA. This critical review provides a direct comparison of SDA with other dietary (n-3) PUFA under similar experimental conditions. The comparative results suggest that SDA shares many of the biological effects of (n-3) LCPUFA and functions most similarly to dietary EPA compared with ALA when consumed in a typical Western diet. Therefore, although SDA may not replace fish as a major dietary source of (n-3) LCPUFA, it could become a prominent surrogate for EPA in the commercial development of foods fortified with (n-3) PUFA.