Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
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DOI：
10.1038/373
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发表时间：
1998-06-01
影响因子：
25
通讯作者：
Schwab, ME
中科院分区：
文献类型：
--
作者：
Thallmair, M;Metz, GAS;Schwab, ME
啮齿类动物皮质脊髓束（CST）损伤后的解剖可塑性和功能恢复在出生后与髓鞘形成平行减少。髓鞘相关的神经突生长抑制蛋白阻止再生纤维的生长，但它们是否也阻止未损伤纤维的反应性发芽尚不清楚。在这里，我们表明，单侧CST病变后，在成年大鼠脑干，完整和病变的道显示地形适当的发芽后，用单克隆抗体，中和这些抑制蛋白质的治疗。抗体治疗的动物在运动和感觉测试中表现出完全恢复，而未治疗的病变大鼠表现出持续的严重缺陷。因此，髓鞘相关的神经突生长抑制剂的中和恢复了成年人通常只在围产期发现的结构可塑性和功能恢复。
Anatomical plasticity and functional recovery after lesions of the rodent corticospinal tract (CST) decrease postnatally in parallel with myelin formation. Myelin-associated neurite growth inhibitory proteins prevent regenerative fiber growth, but whether they also prevent reactive sprouting of unlesioned fibers is less clear. Here we show that after unilateral CST lesion in the adult rat brainstem, both intact and lesioned tracts show topographically appropriate sprouting after treatment with a monoclonal antibody that neutralizes these inhibitory proteins. Antibody-treated animals showed full recovery in motor and sensory tests, whereas untreated lesioned rats exhibited persistent severe deficits. Neutralization of myelin-associated neurite growth inhibitors thus restores in adults the structural plasticity and functional recovery normally found only at perinatal ages.