ABSORPTION OF FRUCTOSE BY ISOLATED SMALL-INTESTINE OF RATS IS VIA A SPECIFIC SATURABLE CARRIER IN THE ABSENCE OF GLUCOSE AND BY THE DISACCHARIDASE-RELATED TRANSPORT-SYSTEM IN THE PRESENCE OF GLUCOSE
ABSORPTION OF FRUCTOSE BY ISOLATED SMALL-INTESTINE OF RATS IS VIA A SPECIFIC SATURABLE CARRIER IN THE ABSENCE OF GLUCOSE AND BY THE DISACCHARIDASE-RELATED TRANSPORT-SYSTEM IN THE PRESENCE OF GLUCOSE
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DOI：
10.1093/jn/125.8.2156
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发表时间：
1995-08-01
影响因子：
4.2
通讯作者：
KRETCHMER, N
中科院分区：
文献类型：
--
作者：
USHIJIMA, K;RIBY, JE;KRETCHMER, N
以前的研究表明，果糖的吸收是通过同时摄入葡萄糖来帮助的。本研究的目的是在体外重现这一发现，以更好地了解葡萄糖对果糖吸收的影响机制。这种现象不能用外翻的大鼠肠袖或刷状缘囊泡再现。在离体肠的灌注段中，可以证明当葡萄糖存在于灌注介质中时，果糖的转运加速。增强运输抑制蔗糖，也由阿卡巴松，肠道α-dispylidases的抑制剂。根皮苷对果糖的转运无影响。这些研究的结果表明，有一个特定的载体，果糖饱和低浓度的糖，并在葡萄糖的存在下，有联合吸收的两种糖的dispensidase相关的运输系统。
Previous studies have shown that the absorption of fructose is aided by simultaneous ingestion of glucose. The aim of the present study was to reproduce this finding in vitro to better understand the mechanism of the effect of glucose on absorption of fructose. The phenomena could not be reproduced with everted sleeves of rat intestine or brush border vesicles. In a perfused segment of isolated intestine, it was possible to demonstrate that the transport of fructose was accelerated when glucose was present in the perfusion medium. The enhanced transport was inhibited by sucrose and also by acarbazone, an inhibitor of intestinal alpha-disaccharidases. Phlorizin had no effect on the transport of fructose. The results of these studies indicate that there is a specific carrier for fructose saturated with a low concentration of the sugar, and that in the presence of glucose there is joint absorption of the two sugars by the disaccharidase-related transport system.