Fat intake modulates cerebral blood flow in homeostatic and gustatory brain areas in humans
Fat intake modulates cerebral blood flow in homeostatic and gustatory brain areas in humans
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DOI：
10.3945/ajcn.111.031492
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发表时间：
2012-06-01
影响因子：
7.1
通讯作者：
Veit, Ralf
中科院分区：
文献类型：
--
作者：
Frank, Sabine;Linder, Katarzyna;Veit, Ralf
背景：下丘脑是大脑的中央稳态控制区域，因此受葡萄糖和脂肪等营养物质的影响很大。葡萄糖摄入的即时和长期稳态效应已得到充分表征。然而，使用脂肪刺激的研究主要调查即时感知过程。除了稳态过程外，味觉皮层（包括部分岛叶皮层）对于食物的加工也至关重要。目的：本研究的目的是调查高脂膳食与低脂膳食对下丘脑和岛叶皮层的影响。设计：11 名健康男性在 2 个测量日参加了一项高脂和低脂膳食的单盲功能性 MRI 研究。在摄入高脂和低脂酸奶之前以及摄入后 30 分钟和 120 分钟测量脑血流量 (CBF)。在每次CBF测量前对饥饿程度进行评级并采集血样。结果：高脂酸奶引起下丘脑CBF显着降低，并且相应的CBF变化与胰岛素变化呈正相关。此外，仅在低脂条件下 120 分钟后，岛叶活性才增加。在高脂肪条件下，两个区域的CBF变化呈正相关。结论：脂肪引起的下丘脑活动的减少以及与岛叶皮质的相互作用可能有助于有效的能量稳态。因此，脂肪可能是大脑稳态和味觉区域及其相互作用的调节剂。该试验在 ClinicalTrials.gov 上注册为 NCT01516021。美国临床营养杂志 2012；95：1342-9。
Background: The hypothalamus is the central homeostatic control region of the brain and, therefore, highly influenced by nutrients such as glucose and fat. Immediate and prolonged homeostatic effects of glucose ingestion have been well characterized. However, studies that used stimulation with fat have mainly investigated immediate perceptional processes. Besides homeostatic processes, the gustatory cortex, including parts of the insular cortex, is crucial for the processing of food items.Objective: The aim of this study was to investigate the effect of high- compared with low-fat meals on the hypothalamus and the insular cortex.Design: Eleven healthy men participated in a single-blinded, functional MRI study of high- and low-fat meals on 2 measurement days. Cerebral blood flow (CBF) was measured before and 30 and 120 min after intake of high- and low-fat yogurts. Hunger was rated and blood samples were taken before each CBF measurement.Results: High-fat yogurt induced a pronounced decrease in CBF in the hypothalamus, and the corresponding CBF change correlated positively with the insulin change. Furthermore, insular activity increased after 120 min in the low-fat condition only. The CBF change in both regions correlated positively in the high-fat condition.Conclusions: The decrease in hypothalamic activity and the interaction with the insular cortex elicited by fat may contribute to an efficient energy homeostasis. Therefore, fat might be a modulator of homeostatic and gustatory brain regions and their interaction. This trial was registered at clinicaltrials.gov as NCT01516021. Am J Clin Nutr 2012;95:1342-9.