A multi-dose study on the human metabolism of amylobarbitone.
A multi-dose study on the human metabolism of amylobarbitone.
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戊巴比妥人体代谢的多剂量研究。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
J. Powell
中科院分区：
文献类型：
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作者：
W. Baldeo;J. Gilbert;J. Powell
1. 在两名健康男性志愿者中研究了戊巴比妥的代谢，并在每位志愿者服用三剂后四天定量测定原药的尿排泄以及 omega 和 omega-1 氧化产物。 2. 与布托巴比妥的观察结果相反，支链淀粉巴比妥对其自身代谢率几乎没有影响。 3.母药尿排泄的t 1/2 为16.3 h，而两种代谢物的t 1/2 为22.2 h。
1. The metabolism of amylobarbitone has been investigated in two healthy male volunteers, and the urinary excretion of unchanged drug, and the products of omega and omega-1 oxidation, quantitatively determined for four days after each of three doses to each volunteer. 2. In contrast to observations with butobarbitone, amylobarbitone was shown to have little effect on the rate of its own metabolism. 3. The t 1/2 for urinary excretion of the parent drug was 16.3 h while that for the two metabolites was 22.2 h.