MOUSE FIBROBLAST INTERFERON MODIFIES SALMONELLA-TYPHIMURIUM INFECTION IN INFANT MICE
MOUSE FIBROBLAST INTERFERON MODIFIES SALMONELLA-TYPHIMURIUM INFECTION IN INFANT MICE
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DOI：
10.1128/iai.45.1.62-66.1984
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
DEGRE, M
中科院分区：
文献类型：
--
作者：
BUKHOLM, G;BERDAL, BP;DEGRE, M
The effect of mouse fibroblast interferon on S. typhimurium infection in infant mice was examined. The lethality to mice that had been given S. typhimurium intragastrically was significantly reduced in a dose-dependent manner when the mice were pretreated with fibroblast interferon. Lower doses of interferon delayed the development of disease. Interferon neutralized with anti-interferon globulin did not influence the lethality of S. typhimurium to mice. In mice treated with interferon there was also a reduced invasiveness of S. typhimurium in intestinal epithelial cells in vivo. In an in vitro system, interferon pretreatment of mouse L-929 cells inhibited the invasiveness of the bacteria in a dose-dependent manner. The in vitro inhibition was neutralized with anti-interferon globulin. Evidently, interferon inhibits Salmonella bacteria from invading cells and establishing an intracellular state of infection. This may represent an important factor in the pathogenesis of disease.
