Volatile anesthetics directly activate baseline S K+ channels in aplysia neurons.
Volatile anesthetics directly activate baseline S K+ channels in aplysia neurons.
复制标题
挥发性麻醉剂直接激活海兔神经元中的基线 S K 通道。
DOI：
10.1016/s0006-8993(98)00687-8
复制
发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Yost,CS
中科院分区：
文献类型：
--
作者：
Winegar,BD;Yost,CS
The actions of halothane on serotonin-sensitive potassium channels (S K+channels) were studied in sensory neurons of Aplysia. The normalized open probability of S K+channels was increased by clinical concentrations of halothane in cell-attached and excised patches from neurons of the pleural ventrocaudal cluster. No voltage-dependence of channel activation by halothane was observed. Pre-treatment of neurons with 8-bromo-cAMP (8-Br-cAMP) or nordihydroguaiaretic acid (NDGA) had no effect on the relative level of channel activation by halothane. S K+channels that were activated by arachidonic acid could also be activated by halothane and exhibited closely similar amplitude distributions of open channel current. Results from these experiments showed that S K+channel activation by halothane did not depend on second messenger modulation of channel activity. We conclude that it is likely that halothane directly activates S K+channels.
