Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla
Xishacorenes A-C, Diterpenes with Bicyclo[3.3.1]nonane Nucleus from the Xisha Soft Coral Sinularia polydactyla
复制标题
西沙软珊瑚Sinularia polydactyla中的西沙核烯A-C、双环[3.3.1]壬烷核二萜
DOI：
10.1021/acs.orglett.7b01716
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发表时间：
2017-08-18
期刊：
影响因子：
5.2
通讯作者：
Guo, Yue-Wei
中科院分区：
文献类型：
--
作者：
Ye, Fei;Zhu, Zheng-Dan;Guo, Yue-Wei
Three new diterpenes, xishacorenes A-C, featuring an undescribed bicyclo[3.3.1]nonane nucleus bearing 1-vinyl and 13-[(E)-4-methylpenta-1,3-dien-1-yl] alkyl chains, and a related monocyclic known compound, were isolated from the Xisha soft coral Sinularia polydactyla. The structures of xishacorenes A-C, including their absolute configurations, were elucidated by extensive spectroscopic analysis and TDDFT ECD calculations. The new compounds exhibit an interesting dose-dependent promotion effect on the ConA-induced T lymphocyte proliferation. A plausible biosynthetic pathway of xishacorenes A-C is proposed.
