Genetic, environmental, and behavioral correlates of lifetime suicide attempt: Analysis of additive and interactive effects in two cohorts of US Army soldiers.
Genetic, environmental, and behavioral correlates of lifetime suicide attempt: Analysis of additive and interactive effects in two cohorts of US Army soldiers.
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DOI：
10.1038/s41386-023-01596-2
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发表时间：
2023-10
影响因子：
7.6
通讯作者：
Stein, Murray B.
中科院分区：
文献类型：
--
作者：
Campbell-Sills, Laura;Sun, Xiaoying;Papini, Santiago;Choi, Karmel W.;He, Feng;Kessler, Ronald C.;Ursano, Robert J.;Jain, Sonia;Stein, Murray B.
最近发展的自杀企图遗传倾向的测量方法可能传达关于个人自杀行为风险的独特信息。我们计算了参加陆军STARRS新兵研究（NSS; n = 6573）或部署前/后研究（PPDS; n = 4900）的欧洲血统士兵自杀企图的多基因风险评分（SA-PRS）。在每个样本中拟合多变量logistic回归模型，以估计SA-PRS与终生自杀企图（LSA）的关联，并检验SA-PRS是否与环境和行为风险/保护因素（终生创伤负担、童年虐待、负紧急冲动、社会网络规模、感知问题和性格乐观）表现出相加或交互作用。协变量包括年龄、性别和血统内变异。在NSS和PPDS样本中观察到的LSA患病率分别为6.3%和4.2%。在NSS模型中，SA-PRS和环境/行为因素对LSA的概率表现出严格的加性效应。结果显示，SA-PRS每增加1 SD， LSA的几率估计增加21%[校正优势比(AOR; 95% CI) = 1.21(1.09-1.35)]。在PPDS中，SA-PRS的效果因乐观报告而异[SA-PRS x乐观效应的AOR = 0.85(0.74-0.98)]。报告低乐观和平均乐观的个体，SA-PRS每增加1 SD， LSA的几率分别增加37%和16%，而报告高乐观的个体，SA-PRS与LSA无关。总的来说，结果表明SA-PRS对LSA的预测价值超过了一些环境和行为风险因素。此外，SA-PRS升高可能在存在环境和行为风险因素（例如，高创伤负担；低乐观）的情况下更为令人担忧。由于影响幅度相对较小，在未来的工作中还必须考虑利用SA-PRS进行风险定位的成本和增量收益。
Recently developed measures of genetic liability to suicide attempt may convey unique information regarding an individual’s risk of suicidal behavior. We calculated a polygenic risk score for suicide attempt (SA-PRS) for soldiers of European ancestry who participated in the Army STARRS New Soldier Study (NSS; n = 6573) or Pre/Post Deployment Study (PPDS; n = 4900). Multivariable logistic regression models were fit within each sample to estimate the association of SA-PRS with lifetime suicide attempt (LSA), and to examine whether SA-PRS displayed additive or interactive effects with environmental and behavioral risk/protective factors (lifetime trauma burden, childhood maltreatment, negative urgency impulsivity, social network size, perceived mattering, and dispositional optimism). Age, sex, and within-ancestry variation were included as covariates. Observed prevalence of LSA was 6.3% and 4.2% in the NSS and PPDS samples, respectively. In the NSS model, SA-PRS and environmental/behavioral factors displayed strictly additive effects on odds of LSA. Results indicated an estimated 21% increase in odds of LSA per 1 SD increase in SA-PRS [adjusted odds ratio (AOR; 95% CI) = 1.21 (1.09–1.35)]. In PPDS, the effect of SA-PRS varied by reports of optimism [AOR = 0.85 (0.74–0.98) for SA-PRS x optimism effect]. Individuals reporting low and average optimism had 37% and 16% increased odds of LSA per 1 SD increase in SA-PRS, respectively, whereas SA-PRS was not associated with LSA in those reporting high optimism. Overall, results suggested the SA-PRS had predictive value over and above several environmental and behavioral risk factors for LSA. Moreover, elevated SA-PRS may be more concerning in the presence of environmental and behavioral risk factors (e.g., high trauma burden; low optimism). Given the relatively small effect magnitudes, the cost and incremental benefits of utilizing SA-PRS for risk targeting must also be considered in future work.
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DOI：
10.1002/ajmg.b.32917
发表时间：
2022-10
影响因子：
2.8
作者：
Mirza, Salahudeen;Docherty, Anna R.;Bakian, Amanda;Coon, Hilary;Soares, Jair C.;Walss-Bass, Consuelo;Fries, Gabriel R.
通讯作者：
Fries, Gabriel R.
影响因子：
13.8
作者：
Joo YY;Moon SY;Wang HH;Kim H;Lee EJ;Kim JH;Posner J;Ahn WY;Choi I;Kim JW;Cha J
通讯作者：
Cha J
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
6.9
作者：
Rosellini, A. J.;Stein, M. B.;Kessler, R. C.
通讯作者：
Kessler, R. C.
影响因子：
25.8
作者：
Stein MB;Chen CY;Ursano RJ;Cai T;Gelernter J;Heeringa SG;Jain S;Jensen KP;Maihofer AX;Mitchell C;Nievergelt CM;Nock MK;Neale BM;Polimanti R;Ripke S;Sun X;Thomas ML;Wang Q;Ware EB;Borja S;Kessler RC;Smoller JW;Army Study to Assess Risk and Resilience in Servicemembers (STARRS) Collaborators
通讯作者：
Army Study to Assess Risk and Resilience in Servicemembers (STARRS) Collaborators