Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.
Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis.
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DOI：
10.1186/ar1444
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发表时间：
2004
影响因子：
4.9
通讯作者：
Gaffen, Sarah L
中科院分区：
文献类型：
--
作者：
Gaffen, Sarah L
白细胞介素 - 17及其受体是一个新兴的细胞因子及受体家族的创始成员，具有许多独特特性。白细胞介素 - 17主要由T细胞产生，尤其是记忆细胞群中的T细胞。相比之下，白细胞介素 - 17受体广泛表达，使得几乎所有细胞都成为白细胞介素 - 17的潜在靶标。尽管白细胞介素 - 17与其他细胞因子仅有有限的同源性，但它表现出与肿瘤坏死因子 -α相似的促炎特性，特别是在诱导其他炎症效应因子方面。此外，白细胞介素 - 17与其他细胞因子具有强大的协同作用，使其处于炎症网络的中心位置。引人注目的是，白细胞介素 - 17与多种骨骼疾病相关，其中最显著的是类风湿性关节炎。
IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced primarily by T cells, particularly those of the memory compartment. In contrast, IL-17 receptor is ubiquitously expressed, making nearly all cells potential targets of IL-17. Although it has only limited homology to other cytokines, IL-17 exhibits proinflammatory properties similar to those of tumor necrosis factor-α, particularly with respect to induction of other inflammatory effectors. In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis.