EFFECT OF SODIUM VALPROATE ON MOTOR FUNCTION REGULATED BY THE ACTIVATION OF GABA RECEPTORS
EFFECT OF SODIUM VALPROATE ON MOTOR FUNCTION REGULATED BY THE ACTIVATION OF GABA RECEPTORS
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DOI：
10.1007/bf00431651
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
URETSKY, NJ
中科院分区：
文献类型：
--
作者：
KURUVILLA, A;URETSKY, NJ
丙戊酸钠是一种抗惊厥药，可升高大脑GABA水平。GABA与多巴胺在涉及运动行为的大脑的某些区域（如延髓核和黑质）中功能性地相互作用。为了确定GABA是否在丙戊酸盐的药理学作用中发挥功能作用，将丙戊酸盐和GABA直接注射到这2个脑区，并在大鼠中研究了这些化合物对运动功能的影响。GABA和丙戊酸钠均以剂量依赖性方式抑制由双侧延髓核注射多巴胺诱导的活动过度。印防己毒素是一种GABA拮抗剂，可阻断丙戊酸盐的抑制作用。当注射到黑质网状部时，丙戊酸钠和GABA都增强了6-羟基多巴胺引起的下丘脑外侧单侧病变大鼠的阿扑吗啡诱导的盘旋。这种作用被全身性印防己毒素给药阻断。丙戊酸钠可明显产生激活大脑中GABA受体位点的效应。
Sodium valproate is an anticonvulsant which elevates brain GABA levels. GABA interacts with dopamine functionally in certain areas of the brain involved in motor behavior such as the nucleus accumbens and the substantia nigra. In order to determine whether GABA can play a functional role in the pharmacological effects of valproate, both valproate and GABA were injected directly into these 2 brain areas, and the effects of these compounds on motor function were studied in rats. Both GABA and sodium valproate inhibited in a dose-dependent manner the hyperactivity induced by the bilateral injection of dopamine into the nucleus accumbens. Picrotoxin, a GABA antagonist, blocked the inhibitory effect of valproate. When injected into the pars reticulata of the substantia nigra, both sodium valproate and GABA enhanced apomorphine-induced circling in rats with a unilateral lesion of lateral hypothalamus caused by 6-hydroxydopamine. This effect was blocked by systemic picrotoxin administration. Sodium valproate can evidently produce effects that result from the activation of GABA receptor sites in the brain.