Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.
Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.
复制标题
饮酒与载脂蛋白E（APOE）基因型与中年男性认知之间的相互作用。
DOI：
10.1017/s1355617720000570
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Franz CE
中科院分区：
文献类型：
--
作者：
Slayday RE;Gustavson DE;Elman JA;Beck A;McEvoy LK;Tu XM;Fang B;Hauger RL;Lyons MJ;McKenzie RE;Sanderson-Cimino ME;Xian H;Kremen WS;Franz CE
大量饮酒与老年人认知功能较差有关。尽管在中年人中研究不多，但酒精和认知之间的关系也可能受到遗传因素的影响，例如载脂蛋白(ApoE)ε4等位基因，这是阿尔茨海默病的一个风险因素。我们研究了中年人饮酒量、载脂蛋白E基因和认知之间的关系，并假设轻度和/或中度饮酒者(每天喝2杯≤)将比重度饮酒者或不饮酒者表现出更好的认知表现。此外，我们假设饮酒和认知功能之间的关联将因载脂蛋白E基因(ε4+vs.ε4−)而不同。参与者是来自越南时代双胞胎老龄化研究(Vetsa；男性=56岁；范围51-60)的1266名男性，他们完成了一组神经心理学组件，评估了七种认知能力：一般认知能力、情景记忆、处理速度、执行功能、抽象推理、语言流畅性和视觉空间能力。饮酒被分为五组：从不饮酒、以前饮酒、轻度饮酒、中度饮酒和重度饮酒。在完全调整的模型中，饮酒对认知功能没有显著的主要影响。但在一般认知能力和情景记忆方面，饮酒与载脂蛋白Eε4状态之间存在显著的交互作用，因此在ε4携带者中饮酒与认知的关系更强。ε4+重度饮酒亚组的一般认知能力和情景记忆能力最差。ε4等位基因的存在可能会增加人们对大量饮酒有害影响的易感性。没有观察到轻度或中度饮酒的有益影响。
Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) ε4 allele, a risk factor for Alzheimer’s disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would show better cognitive performance than heavy drinkers or non-drinkers. Additionally, we hypothesized that the association between alcohol use and cognitive function would differ by ApoE genotype (ε4+ vs. ε4−). Participants were 1,266 men from the Vietnam Era Twin Study of Aging (VETSA; M age = 56; range 51-60) who completed a neuropsychological battery assessing seven cognitive abilities: general cognitive ability, episodic memory, processing speed, executive function, abstract reasoning, verbal fluency, and visuospatial ability. Alcohol consumption was categorized into five groups: never, former, light, moderate, and heavy. In fully adjusted models, there was no significant main effect of alcohol consumption on cognitive functions. However, there was a significant interaction between alcohol consumption and ApoE ε4 status for general cognitive ability and episodic memory, such that the relationship of alcohol consumption and cognition was stronger in ε4 carriers. The ε4+ heavy drinking subgroup had the poorest general cognitive ability and episodic memory. Presence of the ε4 allele may increase vulnerability to the deleterious effects of heavy alcohol consumption. Beneficial effects of light or moderate alcohol consumption were not observed.