Long non-coding RNAs in hematopoietic regulation.
Long non-coding RNAs in hematopoietic regulation.
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长链非编码RNA在造血调节中的作用
DOI：
10.1016/j.cr.2018.08.001
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发表时间：
2018-12-01
期刊：
影响因子：
--
通讯作者：
Yu, Jia
中科院分区：
文献类型：
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作者：
Li, Weiqian;Ren, Yue;Yu, Jia
长链非编码RNA（lncRNA）通过与DNA、RNA或蛋白质的连接在多种生物过程中发挥重要作用。这些lncRNA介导的相互作用增强了基因调控网络，并调节了广泛的下游基因。已经证明几种lncRNA在造血中起关键调节剂的作用。本文综述了lncRNA在正常造血发育中的作用，并讨论了lncRNA失调与疾病的发生和表型的关系。
Long non-coding RNAs (lncRNAs) have crucial roles via tethering with DNA, RNA or protein in diverse biological processes. These lncRNA-mediated interactions enhance gene regulatory networks and modulate a wide range of downstream genes. It has been demonstrated that several lncRNAs act as key regulators in hematopoiesis. This review highlights the roles of lncRNAs in normal hematopoietic development and discusses how lncRNA dysregulation correlates with disease prognoses and phenotypes.