Prevalence of Risk Factors for Cardiovascular Diseases in Bangladesh: A Systematic Review and Meta-Analysis.
Prevalence of Risk Factors for Cardiovascular Diseases in Bangladesh: A Systematic Review and Meta-Analysis.
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DOI：
10.1371/journal.pone.0160180
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Rahman B
中科院分区：
文献类型：
--
作者：
Fatema K;Zwar NA;Milton AH;Ali L;Rahman B
鉴于孟加拉国心血管疾病（CVD）的发病率不断上升，需要更好地了解CVD危险因素的流行病学。因此，我们回顾了已发表的关于CVD可改变风险因素的研究，例如，2型糖尿病（T2 DM）、高血压（HTN）、血脂异常和吸烟以及心血管疾病研究，并对风险因素和疾病患病率进行了荟萃分析。我们检索了GLOBAL HEALTH、MEDLINE、EMBASE 'BanglaJol'数据库中关于CVD及其相关可改变风险因素的所有英文研究。随机效应荟萃分析方法用于估计合并患病率。共有74项合格研究（结局：T2 DM = 32，HTN = 24，血脂异常= 8，吸烟= 25; CVD = 10）。由于CVD危险因素患病率的研究间异质性较高（p<0.001，I2> 95%），我们采用中位数和四分位距（IQR）代替汇总估计值作为汇总指标。T2 DM、HTN、血脂异常和吸烟的中位（IQR）患病率分别为5.9%（1.97%-8.25%）、15.1%（10.52%-17.60%）、34.35%（10.66%-48.50%）和40.56%（0.80%-55.95%）。城市人群中T2 DM和血脂异常的患病率显著高于农村人群（分别为13.5% vs 6%，p<0.001; 41.5% vs 30%，p = 0.007）。在孟加拉国，心血管疾病危险因素的流行率很高，在城市地区更是如此。人口老龄化可能是一个因素，但城市化似乎也有影响，可能与饮食和体育活动模式的变化有关。需要进一步研究，特别是纵向研究，以探索这些因素的复杂相互作用，并为孟加拉国预防和管理心血管疾病的政策和计划提供信息。
Given the rising incidence of cardiovascular diseases (CVDs) in Bangladesh, an improved understanding of the epidemiology of CVD risk factors is needed. Therefore, we reviewed published studies on CVD modifiable risk factors e.g., Type 2 Diabetes Mellitus (T2DM), hypertension (HTN), dyslipidemia and smoking as well as studies on CVDs and conducted a meta-analysis of risk factors and disease prevalence. We searched the GLOBAL HEALTH, MEDLINE, EMBASE ‘BanglaJol’ databases for all studies in English on CVDs and its associated modifiable risk factors. Random effects meta-analysis methods were used to estimate pooled prevalence. There were 74 eligible studies (outcome: T2DM = 32, HTN = 24, dyslipidaemia = 8 and smoking = 25; CVDs = 10). Due to high between study heterogeneity (p<0.001, I2> 95%) in the prevalence of CVD risk factors, we presented median and interquartile range (IQR) instead of the pooled estimates as the summary measures. Median (IQR) prevalence of T2DM, HTN, dyslipidemia and smoking were 5.9% (1.97%-8.25%); 15.1% (10.52%-17.60%); 34.35% (10.66%-48.50%) and 40.56% (0.80%-55.95%), respectively. The prevalence of T2DM and dyslipidemia were significantly higher in urban compared to rural populations (13.5 vs 6%, p<0.001; 41.5 vs 30%, p = 0.007, respectively). The prevalence of risk factors for CVDs is high in Bangladesh, more so in urban areas. Ageing of the population may be a factor but urbanization seems to have an influence, possibly related to changes in dietary and physical activity patterns. Further research, in particular longitudinal studies, is needed to explore the complex interaction of these factors and to inform policies and programs for the prevention and management of CVDs in Bangladesh.