Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population.
Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population.
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中国汉族人群精神分裂症患者与对照者血清微量元素差异
DOI：
10.1038/srep15013
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发表时间：
2015-10-12
影响因子：
4.6
通讯作者：
Wan C
中科院分区：
文献类型：
--
作者：
Cai L;Chen T;Yang J;Zhou K;Yan X;Chen W;Sun L;Li L;Qin S;Wang P;Yang P;Cui D;Burmeister M;He L;Jia W;Wan C
关于精神分裂症患者和健康对照之间的微量元素分布差异知之甚少;以前关于某些元素与精神分裂症的关联的研究获得了相互矛盾的结果。为了确定这些差异在中国汉族人群中，电感耦合等离子体质谱法被用来量化的35种元素的水平在111例精神分裂症患者和110名健康参与者，其中包括培训（61/61例病例/对照组）和测试组，包括其余的参与者的血清。训练组的潜伏结构正交投影模型（R2 Y = 0.465，Q2 cum = 0.343）的敏感性为76.0%，特异性为71.4%。单元素分析表明，无论是训练组还是试验组，精神分裂症患者体内铯、锌、硒的浓度均显著降低。包括522例病例和360例对照的荟萃分析支持在随机效应模型中锌与精神分裂症显著相关（标准化均值差[SMD]，-0.81; 95%置信区间[CI]，-1.46至-0.16，P = 0.01）。信息论分析表明锌在精神分裂症中可能独立发挥作用。这些结果表明，精神分裂症患者和健康对照组之间存在明显的元素谱差异，并证实了精神分裂症患者的锌水平降低。
Little is known about the trace element profile differences between Schizophrenia patients and healthy controls; previous studies about the association of certain elements with Schizophrenia have obtained conflicting results. To identify these differences in the Han Chinese population, inductively coupled plasma-mass spectrometry was used to quantify the levels of 35 elements in the sera of 111 Schizophrenia patients and 110 healthy participants, which consisted of a training (61/61 for cases/controls included) and a test group including remaining participants. An orthogonal projection to latent structures model was constructed from the training group (R2Y = 0.465, Q2cum = 0.343) had a sensitivity of 76.0% and a specificity of 71.4% in the test group. Single element analysis indicated that the concentrations of cesium, zinc and selenium were significantly reduced in patients with Schizophrenia in both the training and test groups. The meta-analysis including 522 cases and 360 controls supported that Zinc was significantly associated with Schizophrenia (standardized mean difference [SMD], −0.81; 95% confidence intervals [CI], −1.46 to −0.16,P= 0.01) in the random-effect model. Information theory analysis indicated that Zinc could play roles independently in Schizophrenia. These results suggest clear element profile differences between patients with Schizophrenia and healthy controls and reduced Zn level is confirmed in the Schizophrenia patients.