Body Weight Reduction Results in Favorable Changes in Blood Pressure, Serum Lipids, and Blood Sugar in Middle-Aged Japanese Persons: A 5-Year Interval Observational Study of 26,824 Cases.
Body Weight Reduction Results in Favorable Changes in Blood Pressure, Serum Lipids, and Blood Sugar in Middle-Aged Japanese Persons: A 5-Year Interval Observational Study of 26,824 Cases.
复制标题
DOI：
10.5539/gjhs.v7n5p159
复制
发表时间：
2015-02-24
期刊：
影响因子：
--
通讯作者：
Chishaki H
中科院分区：
文献类型：
--
作者：
Mandai N;Akazawa K;Hara N;Ide Y;Ide K;Dazai U;Chishaki A;Chishaki H
我们调查了体重与代谢综合征(MS)危险因素之间的关系，以阐明体重变化(ΔBWT)和体重指数对这些因素的影响。2006年和2011年在日本福冈对16640名男性(平均年龄：41.7±11.6岁)和10184名女性(平均年龄：45.0±12.2岁)进行了两次年度检查，测量了MS相关参数的数据，这些人之前没有接受过高血压、糖尿病或血脂异常的治疗。受试者根据2006年的BMI分为三组(低、中、高BMI)，并根据2006-2011年间BMI的变化分为三组(BMI下降、稳定和增加)。按性别测定血压(BP)、收缩压(SBP)、舒张压(DBP)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)的平均值，并进行统计学分析比较。在男女中，高BMI(>；26)与较高的SBP、LDL-C、FBG和TG相关。DBP、≥-C、TG、HbA1c、Fbg在5年内增加1.1BMI单位，HDLc降低。相反，体重指数的降低与血压和低密度脂蛋白胆固醇的降低以及高密度脂蛋白胆固醇的升高有关，而男性的甘油三酯和女性的空腹血糖降低。保持理想的体重或减肥可能有助于预防高血压和多发性硬化症，即使是在非肥胖的人中也是如此。
We investigated the relationships between body weight (BWt) and metabolic syndrome (MS) risk factors to elucidate the effect of BWt (ΔBWt) change and body mass index (BMI) on these factors in the Japanese population. Data were collected on MS-related parameters measured during two annual examinations of 16,640 men (mean age: 41.7±11.6 years) and 10,184 women (mean age: 45.0±12.2 years) without prior treatment of hypertension, diabetes mellitus, or dyslipidemia in 2006 and 2011 in Fukuoka, Japan. The subjects were divided into three groups according to BMI in 2006 (low, middle and high BMI) and into three groups according to change in BMI between 2006 and 2011 (decreased, stable, and increased BMI). Mean values for blood pressure (BP), systolic BP (SBP), diastolic BP (DBP), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), hemoglobin A1c (HbA1c), and fasting blood glucose (FBG) for each group were determined by sex and subjected to statistical analysis for comparison. High BMI (>26) was associated with higher SBP, LDL-C, FBG, and TG in both sexes. An increase ≥ 1.1 BMI units in 5 years was associated with increased DBP, LDL-C, TG, HbA1c, and FBG and decreased HDL-C. In contrast, decreased BMI was associated with decreased BP and LDL-C and increased HDL-C in both sexes, and decreased TG in men and FBG in women. Maintaining a desirable weight or losing weight may help prevent hypertension and MS, even in non-obese individuals.