Ly6G+ Neutrophils Are Dispensable for Defense against Systemic Listeria monocytogenes Infection
Ly6G+ Neutrophils Are Dispensable for Defense against Systemic Listeria monocytogenes Infection
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DOI：
10.4049/jimmunol.1101721
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发表时间：
2011-11-15
影响因子：
4.4
通讯作者：
Pamer, Eric G.
中科院分区：
文献类型：
--
作者：
Shi, Chao;Hohl, Tobias M.;Pamer, Eric G.
单核细胞增生李斯特菌是一种兼性胞内细菌，可引起免疫功能低下宿主的全身性感染。骨髓细胞，包括炎性单核细胞和中性粒细胞，早期募集到L。单核细胞增多症感染对于控制感染和宿主存活是必需的。由于先前的实验研究使用了消耗或阻断同时影响炎症单核细胞和中性粒细胞的抗体，这些细胞群对防御L。单核细胞增多症感染仍然不完全确定。在这篇文章中，我们使用了高选择性的清除策略来清除淋巴细胞中的炎症单核细胞或中性粒细胞。单核细胞增多症感染的小鼠，并证明嗜中性粒细胞被激活用于感染的早期和晚期控制。相反，炎症单核细胞在对L.单核细胞增多症免疫学杂志，2011，187：5293-5298。
Listeria monocytogenes is a facultative intracellular bacterium that causes systemic infections in immunocompromised hosts. Early recruitment of myeloid cells, including inflammatory monocytes and neutrophils, to sites of L. monocytogenes infection is essential for the control of infection and host survival. Because previous experimental studies used depleting or blocking Abs that affected both inflammatory monocytes and neutrophils, the relative contributions of these cell populations to defense against L. monocytogenes infection remain incompletely defined. In this article, we used highly selective depletion strategies to either deplete inflammatory monocytes or neutrophils from L. monocytogenes-infected mice and demonstrate that neutrophils are dispensable for early and late control of infection. In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection. The Journal of Immunology, 2011, 187: 5293-5298.