New insights into the control of mRNA decapping
New insights into the control of mRNA decapping
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DOI：
10.1016/j.tibs.2006.03.001
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发表时间：
2006-05-01
影响因子：
13.8
通讯作者：
Seraphin, Bertrand
中科院分区：
文献类型：
--
作者：
Simon, Ernesto;Camier, Sylvie;Seraphin, Bertrand
mRNA脱帽不可逆地靶向mRNA快速衰减。脱帽是由脱帽蛋白Dcp2催化的，但也需要Dcp1。最近，两组研究人员首次揭示了基因表达这一关键步骤的调控机制。酵母Dcp2结构的解析能够鉴定出与Dcp1相互作用重要的残基。然而，人类的脱帽机制似乎更复杂，因为第三个成分hedi是Dcp1-Dcp2功能性相互作用所必需的。
mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression. Resolution of the yeast Dcp2 structure has enabled identification of the residues that are important for its interaction with Dcp1. However, the human decapping machinery seems to be more complex because a third component, HedIs, is required for a functional Dcp1-Dcp2 interaction.