Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry
Pore size distributions of biodegradable polymer microparticles in aqueous environments measured by NMR cryoporometry
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DOI：
10.1016/j.ijpharm.2005.11.027
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发表时间：
2006-02-17
影响因子：
5.8
通讯作者：
Daicic, J
中科院分区：
文献类型：
--
作者：
Petrov, O;Furó, I;Daicic, J
核磁共振冻孔法是一种独特的方法，允许在微孔和介孔制度的水环境样品的孔隙调查。在这里，我们将该技术应用于多孔可生物降解的聚合物微粒，设计为储存配方中的药物输送装置。结果表明，利用该技术可以获得表面和裂缝图像中无法捕获的微小结构特征，并且可以研究颗粒在水环境中膨胀和降解过程中孔隙结构的演变。(c) 2005 Elsevier B.V.版权所有
NMR cryoporometry is a unique method permitting the investigation of pores in the microporous and mesoporous regimes for samples in aqueous environments. Here, we apply the technique to porous biodegradable polymer microparticles designed as devices for drug delivery in depot formulations. The results indicate that structural features too small to be captured in surface and fracture images obtained by SEM are able to be accessed using the technique, and that the evolution of pore structure can be studied for several days as the particles swell and degrade in the aqueous environment. (c) 2005 Elsevier B.V. All rights reserved.