A GENETIC PATHWAY FOR THE DEVELOPMENT OF THE CAENORHABDITIS-ELEGANS HSN MOTOR NEURONS
A GENETIC PATHWAY FOR THE DEVELOPMENT OF THE CAENORHABDITIS-ELEGANS HSN MOTOR NEURONS
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DOI：
10.1038/336638a0
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发表时间：
1988-12-15
期刊：
影响因子：
64.8
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
DESAI, C;GARRIGA, G;HORVITZ, HR
35个基因定义了秀丽隐杆线虫雌雄同体特异性神经元（HSNs）发育的途径。这些基因中的一些仅影响一种HSN性状，表明HSN迁移、轴突生长和5-羟色胺表达在HSN发育中是相互独立的事件，其他基因（其中一些是调节性的）影响多种HSN性状。几乎所有的都是多效性的，这表明指定HSN发育的基因在其他细胞类型的发育中也起作用。
Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) inCaenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axonal outgrowth and serotonin expression are mutually independent events in HSN development', others, some of which are regulatory, affect multiple HSN traits. Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types.