Contributions of nerves and metabolites to exercise vasodilation: a unifying hypothesis.
Contributions of nerves and metabolites to exercise vasodilation: a unifying hypothesis.
复制标题
神经和代谢物对运动血管舒张的贡献：一个统一的假设。
DOI：
10.1152/ajpheart.1979.236.5.h705
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
C. R. Honig
中科院分区：
文献类型：
--
作者：
C. R. Honig
神经细胞体存在于骨骼肌的小动脉中，并在相性收缩时启动血管舒张。以下结果表明，在自由血流持续的阶段性收缩过程中，是固有神经而不是代谢物维持血管舒张。1)在某些条件下，在没有检测到代谢产物释放的情况下，可以发生最大的血管舒张。2)当代谢产物在运动中被释放时，它们在血液或组织中的浓度并不总是决定血管舒张的程度。3)局部麻醉剂可部分阻断持续收缩时的血管舒张。阻滞程度与代谢物浓度成反比。剂量、阻滞时间和其他特异性试验表明，局麻药作用于固有神经而不是平滑肌或横纹肌。当收缩停止时，神经源性血管舒张迅速消退（一半时间小于1分钟）。因此，在恢复期间持续的血管舒张完全是由代谢物引起的。提出了一种假设，整合了外在神经、内在神经和代谢物在支持肌肉收缩中的作用。
Neuronal cell bodies exist in arterioles of skeletal muscle and appear to initiate vasodilation during phasic contraction. The following findings indicate that intrinsic nerves rather than metabolites maintain vasodilation during sustained phasic contraction with free flow. 1) Under certain conditions maximal vasodilation can occur without detectable release of metabolites. 2) When metabolites are released during exercise, their concentrations in blood or tissue do not always determine the extent of vasodilation. 3) Vasodilation during sustained contraction can be partly blocked by local anesthetics. The extent of block is inversely proportional to the concentration of metabolites. Dose, time course of block, and other tests of specificity indicate that local anesthetics act on the intrinsic nerves rather than smooth or striated muscle. When contraction stops, neurogenic vasodilation decays rapidly (half time less than 1 min). Sustained vasodilation during recovery is therefore fully accounted for by metabolites. A hypothesis is suggested that integrates the roles of extrinsic nerves, intrinsic nerves, and metabolites in support of muscle contraction.