Aberrant promoter CpG methylation and its translational applications in breast cancer.
Aberrant promoter CpG methylation and its translational applications in breast cancer.
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异常启动子CpG甲基化及其在乳腺癌中的转化应用
DOI：
10.5732/cjc.011.10344
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发表时间：
2013-01
影响因子：
--
通讯作者：
Tao Q
中科院分区：
文献类型：
--
作者：
Xiang TX;Yuan Y;Li LL;Wang ZH;Dan LY;Chen Y;Ren GS;Tao Q
乳腺癌是一种由多种因素驱动的复杂疾病，包括遗传和表观遗传改变。近年来的研究表明，启动子甲基化和组蛋白修饰等表观遗传改变引起的基因异常表达在人类乳腺癌发生中起着至关重要的作用。通过启动子CpG甲基化沉默肿瘤抑制基因（TSGs），促进细胞生长和生存优势，进一步导致肿瘤的发生和进展，从而直接促进乳腺肿瘤的发生。通常，TSGs启动子甲基化异常发生在肿瘤发生早期，可通过药物逆转，因此可能作为乳腺癌早期诊断和靶向治疗的潜在肿瘤标志物。本文就多种tsg在乳腺癌发病过程中的表观遗传变化及其作为肿瘤标志物在乳腺癌早期发现和治疗中的潜在临床应用作一综述。
Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes, including aberrant promoter methylation and histone modification, plays a critical role in human breast Carcinogenesis. Silencing of tumor suppressor genes (TSGs) by promoter CpG methylation facilitates cells growth and survival advantages and further results in tumor initiation and progression, thus directly contributing to breast tumorigenesis. Usually, aberrant promoter methylation of TSGs, which can be reversed by pharmacological reagents, occurs at the early stage of tumorigenesis and therefore may serve as a potential tumor marker for early diagnosis and therapeutic targeting of breast cancer. In this review, we summarize the epigenetic changes of multiple TSGs involved in breast pathogenesis and their potential clinical applications as tumor markers for early detection and treatment of breast cancer.
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