A brief primer on microRNAs and their roles in angiogenesis.
A brief primer on microRNAs and their roles in angiogenesis.
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DOI：
10.1186/2045-824x-5-2
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发表时间：
2013-01-16
期刊：
影响因子：
--
通讯作者：
Anand S
中科院分区：
文献类型：
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作者：
Anand S
血管系统的发育是一个复杂的动态过程，由促血管生成和抗血管生成信号通路的平衡协调。在癌症、炎症和心血管疾病的病理性血管生成过程中，相同的信号通路被错误调节和利用，并导致疾病进展。在过去的十年中，称为microRNA（miR）的小的非编码RNA分子已经成为包括血管生成在内的几种细胞过程的关键调节因子。越来越清楚的是，miR在复杂的网络中起作用，并在mRNA和蛋白质水平上调节基因表达，从而改变对特定刺激的细胞信号传导反应。在脉管系统中，miR可以以促血管生成的方式起作用并增强血管生成，或者通过增强细胞死亡和减少内皮增殖而充当抗血管生成miR。本文综述了microRNA如何调节基因表达的最新进展，并阐述了miR在血管系统中的功能，同时讨论了miR作为抗血管生成治疗剂的潜在应用。
Development of the vasculature is a complex, dynamic process orchestrated by a balance of pro and anti-angiogenic signaling pathways. The same signaling pathways are mis-regulated and exploited during pathological angiogenesis in cancer, inflammation and cardiovascular diseases and contribute to disease progression. In the last decade, small non-coding RNA molecules termed microRNAs (miRs) have emerged as key regulators of several cellular processes including angiogenesis. It is becoming clear that miRs function in complex networks and regulate gene expression both at the mRNA and protein levels thereby altering cellular signaling responses to specific stimuli. In the vasculature, miRs can function either in a pro-angiogenic manner and potentiate angiogenesis or act as anti-angiogenic miRs by enhancing cell death and decreasing endothelial proliferation. This review aims to provide an update on how microRNAs regulate gene expression and illustrate miR function in the vasculature with a discussion of potential applications of miRs as anti-angiogenic therapeutics.