Promises and limitations of immune cell-based therapies in neurological disorders.
Promises and limitations of immune cell-based therapies in neurological disorders.
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DOI：
10.1038/s41582-018-0028-5
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Hu X;Leak RK;Thomson AW;Yu F;Xia Y;Wechsler LR;Chen J
健康的免疫系统维持着自然的检查点来缓和有害的炎症，包括调节性T细胞、调节性B细胞、调节性树突状细胞和小胶质细胞/巨噬细胞/单核细胞。在这里，我们重点介绍了最近发现的调节免疫细胞的有益功能及其作用机制，并评估了它们作为新的基于细胞的脑疾病治疗方法的潜在用途。调节性免疫细胞疗法不仅有可能减轻脑损伤的炎症加剧，而且还可以促进脑损伤后的活跃修复程序。通过利用它们的修复特性，我们可以减少对掩盖临床症状但无法阻止或逆转脑部疾病进展的药物的过度依赖。尽管最近的发现鼓励了对调节性免疫细胞的进一步测试和基因工程用于神经系统疾病的临床管理，但必须克服许多挑战，以提高其在人类中的安全性和有效性。
The healthy immune system maintains natural checkpoints that temper pernicious inflammation, including regulatory T cells, regulatory B cells, regulatory dendritic cells, and microglia/macrophages/monocytes. Here, we highlight recent discoveries on the beneficial functions of regulatory immune cells and their mechanisms of action, and evaluate their potential use as novel cell-based therapies for brain disorders. Regulatory immune cell therapies have the potential to not only mitigate the inflammatory exacerbation of brain injury, but also promote an active post-injury brain repair program. By harnessing their reparative properties, we may reduce over-reliance on medications that mask clinical symptoms but fail to impede or reverse the progression of brain disorders. Although recent discoveries encourage further testing and genetic engineering of regulatory immune cells for the clinical management of neurological disorders, a number of challenges must be surmounted to improve their safety and efficacy in humans.
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