DUAL ENDOCRINE ACTIVITY OF THE TESTES.
DUAL ENDOCRINE ACTIVITY OF THE TESTES.
复制标题
睾丸的双重内分泌活动。
DOI：
10.1126/science.76.1957.19
复制
发表时间：
1932
期刊：
影响因子：
56.9
通讯作者：
D. R. Mccullagh
中科院分区：
文献类型：
--
作者：
D. R. Mccullagh
(6)睾丸水提取物仅含有微量的前列腺再生激素，可防止大鼠去雄后垂体出现细胞变化，并完全抑制垂体功能亢进。(7)睾丸生发上皮的破坏会引起垂体功能亢进，但不会引起第二性腺萎缩。明显且唯一明显的结论是，睾丸分泌一种迄今为止未被认识的水溶性激素，其功能之一是控制垂体。为了便于讨论，有必要区分这两种睾丸激素。使用希腊词根“andros”，将苯可溶性物质命名为“androtin”，这种物质负责第二性腺和其他第二性征的发育和维持。该名称对应于 Doisy 建议的卵巢激素名称“theelin”。水溶性睾丸因子，其特征在于其对垂体的作用，被称为“抑制素”，源自拉丁语动词“inhibere”。
(6) Aqueous testicular extracts, which could have contained no more than an insignificant amount of the prostate-regenerating hormone, prevent the cellular changes from appearing in the pituitary gland after eastration of rats and also completely inhibit the hyperfunction of the pituitary gland.(7) Destruction of the germinal epithelium of the testes will cause pituitary hyperfunction without causing atrophy of the secondary sex glands. The apparent and only obvious conclusion is that the testicle secretes a hitherto unrecognized water soluble hormone, one function of which is a control of the pituitary gland.To facilitate discussion, it is essential that the two testicular hormones be differentiated. Usingthe Greek root" andros" the name" androtin" has been suggested for the benzene soluble substance which is responsible for the development and maintenance of the secondary sex glands and other secondary sex characteristics. This name corresponds in derivation to the name" theelin" suggested by Doisy for the ovarian hormone. The water soluble testicular factor, which is eharacterized by its action on the pituitary gland, has been called" inhibin" from the Latin verb" inhibere."