Effects of Zidovudine and Stavudine on Mitochondrial DNA of Differentiating 3T3-F442a Cells Are Not Associated with Imbalanced Deoxynucleotide Pools
Effects of Zidovudine and Stavudine on Mitochondrial DNA of Differentiating 3T3-F442a Cells Are Not Associated with Imbalanced Deoxynucleotide Pools
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DOI：
10.1128/aac.01115-08
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发表时间：
2009-03-01
影响因子：
4.9
通讯作者：
McKee, Edward E.
中科院分区：
文献类型：
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作者：
Lynx, Matthew D.;LaClair, Darcy D.;McKee, Edward E.
为了检验齐多夫定（3′-azido-3′-脱氧胸腺嘧啶）（AZT）抑制胸腺嘧啶磷酸化是否导致TTP池耗竭从而导致线粒体DNA耗竭，我们将3T3-F442a细胞在AZT存在下分化，分析测定线粒体DNA含量和脱氧核苷酸水平。这些结果表明AZT毒性可能与脱氧核苷酸池改变无关。
To test whether zidovudine (3'-azido-3'-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.