New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar function
New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar function
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DOI：
10.1038/nn1086
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发表时间：
2003-08-01
影响因子：
25
通讯作者：
Yuzaki, M
中科院分区：
文献类型：
--
作者：
Hirai, H;Launey, T;Yuzaki, M
Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To address these issues, we developed an antibody specific for the putative ligand-binding region of GluRdelta2, and application of this antibody to cultured Purkinje cells induced AMPA receptor endocytosis, attenuated synaptic transmission and abrogated long-term depression. Moreover, injection of this antibody into the subarachnoidal supracerebellar space of adult mice caused transient cerebellar dysfunction, such as ataxic gait and poor performance in the rotorod test. These results indicate that GluRdelta2 is involved in AMPA receptor trafficking and cerebellar function in adult mice.
