Relation between circadian patterns in levels of circulating lipoprotein(a), fibrinogen, platelets, and related lipid variables in men
Relation between circadian patterns in levels of circulating lipoprotein(a), fibrinogen, platelets, and related lipid variables in men
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DOI：
10.1016/s0002-8703(00)90324-7
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发表时间：
2000-01-01
影响因子：
4.8
通讯作者：
Olwin, JH
中科院分区：
文献类型：
--
作者：
Bremner, WF;Sothern, RB;Olwin, JH
研究背景：脂蛋白（a）[Lp（a）]浓度与冠状动脉疾病风险之间存在相关性。高浓度的脂蛋白（a）可能是血管或组织损伤的标志物，或可能与其他遗传或环境因素，可导致急性myocardial infarction.Methods我们测量了一组没有临床症状的成年男性志愿者的循环Lp（a），纤维蛋白原，血小板，胆固醇，甘油三酯，高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的昼夜节律特征。我们每3小时采集一次样本，以评估24小时内的正常变化程度，并测试昼夜节律模式的相似性和与Lp（a）水平的相关性。脂蛋白（a）、纤维蛋白原、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇在早晨达到峰值。胆固醇和血小板在下午晚些时候达到峰值，甘油三酯在晚上达到峰值。结论虽然Lp（a）和纤维蛋白原的峰值水平与心肌梗死和中风的早晨峰值频率相一致，血小板峰值似乎与下午晚些时候的心脏性猝死和致命性中风的峰值频率相一致。这些数据表明，适当的单次采样时间可以提高诊断、风险评估和治疗的有用性和准确性。
Background A correlation has been reported between lipoprotein(a) [Lp(a)] concentration and risk for coronary artery disease. High concentrations of Lp(a) might be markers for vascular or tissue injury or might be associated with other genetic or environmental factors that can cause acute myocardial infarction.Methods We measured the circadian characteristics of circulating Lp(a), fibrinogen, platelets, cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol for a group of adult male volunteers who had no clinical symptoms. We obtained samples every 3 hours around the clock to assess the normal degree of variation within a 24 hour period and to test for similarities in circadian patterns and correlations with level of Lp(a).Results Each variable displayed a highly significant circadian rhythm. Lp(a), fibrinogen, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol peaked in the morning. Cholesterol and platelets peaked in the late afternoon, and triglycerides peaked in the evening.Conclusions Although peak levels of Lp(a) and fibrinogen coincide with reported morning peak frequencies of myocardial infarction and stroke, the platelet peak appears to coincide with late afternoon peak frequencies of sudden cardiac death and fatal stroke. The data suggest that proper timing of single samples may improve the usefulness and accuracy of diagnosis, risk assessment, and therapy.