Lateralization of brain activity during lower limb joints movement. An fMRI study
Lateralization of brain activity during lower limb joints movement. An fMRI study
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DOI：
10.1016/j.neuroimage.2006.05.043
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发表时间：
2006-10-01
期刊：
影响因子：
5.7
通讯作者：
Sunaert, Stefan
中科院分区：
文献类型：
--
作者：
Kapreli, Eleni;Athanasopoulos, Spyros;Sunaert, Stefan
对右手受试者的单侧手指运动的研究表明，初级运动皮层和皮层下区域的激活模式不对称。为了研究下肢关节运动过程中是否存在类似模式，使用了功能磁共振成像（fMRI）。十八名健康的右腿优势志愿者参加了一项运动模块设计研究，进行单侧左右重复膝盖、脚踝和脚趾屈曲/伸展运动。为了将下肢关节激活与明确描述的手指运动模式联系起来，还评估了连续的手指与拇指的对抗。所有动作的听觉节奏为 72 次/分钟 (1.2 Hz)。非优势关节运动期间的大脑激活程度比优势关节进行相同运动时的大脑激活程度更高。与下肢关节相比，手指运动具有更强的侧化激活模式，这意味着不同的功能专业化。下肢关节之间的差异也很明显。脚踝和脚趾的运动在大多数被检查的大脑区域中引起了相同程度的磁共振信号变化，而膝关节的运动则与不同的模式相关。最后，初级感觉运动皮层和基底神经节的偏侧化指数受到优势主效应的显着影响，而小脑的偏侧化指数受到关节主效应的显着影响，表明从近端关节到远端关节的偏侧化指数增加。 (c) 2006 年，爱思唯尔公司出版。
Studies of unilateral finger movement in right-handed subjects have shown asymmetrical patterns of activation in primary motor cortex and subcortical regions. In order to investigate the existence of an analogous pattern during lower limb joints movements, functional magnetic resonance imaging (fMRI) was used. Eighteen healthy, right leg dominant volunteers participated in a motor block design study, performing unilateral right and left repetitive knee, ankle and toes flexion/extension movements. Aiming to relate lower limb joints activation to the well-described patterns of finger movement, serial finger-to-thumb opposition was also assessed. All movements were auditory paced at 72 beats/min (1.2 Hz). Brain activation during movement of the nondominant joints was more bilateral than during the same movement performed with the dominant joints. Finger movement had a stronger lateralized pattern of activation in comparison with lower limb joints, implying a different functional specialization. Differences were also evident between the joints of the lower limb. Ankle and toes movements elicited the same extend of MR signal change in the majority of the examined brain regions, whereas knee joint movement was associated with a different pattern. Finally, lateralization index in primary sensorimotor cortex and basal ganglia was significantly affected by the main effect of dominance, whereas the lateralization index in cerebellum was significantly affected by the joint main effect, demonstrating a lateralization index increase from proximal to distal joints. (c) 2006 Published by Elsevier Inc.