IS THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INVOLVED IN THE SODIUM RETENTION IN THE NEPHROTIC SYNDROME
IS THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INVOLVED IN THE SODIUM RETENTION IN THE NEPHROTIC SYNDROME
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DOI：
10.1159/000182827
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发表时间：
1982-01-01
期刊：
影响因子：
2.5
通讯作者：
MACGREGOR, GA
中科院分区：
文献类型：
--
作者：
BROWN, EA;MARKANDU, ND;MACGREGOR, GA
研究了912例处于自发性钠潴留期的肾病综合征患者的钠平衡。保留钠并增加体重3天后，6例患者血浆肾素活性升高；5例患者血浆醛固酮升高或处于正常上限，血容量低于预期。其余6例血浆肾素、醛固酮活性低或正常；其中5例患者血容量大于预期。血浆白蛋白与血浆肾素活性呈显著负相关（r = -0.70, P < 0.02）。肾素-血管紧张素-醛固酮系统在许多肾病综合征患者自发保留钠时不受刺激。在这些患者中，钠潴留可能是由于一些其他机制，可能是肾内的。其他患者肾素-血管紧张素-醛固酮系统的刺激可能是血浆白蛋白降低和血容量减少的代偿机制，而可能不是钠潴留的潜在机制。
Patients (912) with the nephrotic syndrome during a phase of spontaneous Na retention were studied on a Na balance. When retaining Na and gaining weight for > 3 days, 6 patients had an elevated plasma renin activity; plasma aldosterone was elevated or at the upper range of normal, and blood volume was less than predicted in 5. The other 6 patients had a low or normal plasma renin activity and plasma aldosterone; blood volume was greater than predicted in 5 of these patients. There was a significant inverse correlation between plasma albumin and plasma renin activity (r = -0.70, P < 0.02). The renin-angiotensin-aldosterone system is not stimulated in many patients with the nephrotic syndrome when spontaneously retaining Na. In these patients, Na retention is probably due to some other mechanism, possibly intrarenal. Stimulation of the renin-angiotensin-aldosterone system in other patients may be a compensatory mechanism to the lower plasma albumin and reduced blood volume and may not be the underlying mechanism for Na retention.