Not single brain areas but a network is involved in language: Applications in presurgical planning
Not single brain areas but a network is involved in language: Applications in presurgical planning
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DOI：
10.1016/j.clineuro.2018.01.009
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发表时间：
2018-02-01
影响因子：
1.9
通讯作者：
Oghabian, Mohammad Ali
中科院分区：
文献类型：
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作者：
Alemi, Razieh;Batouli, Seyed Amir Hossein;Oghabian, Mohammad Ali
目的：语言是人类的一项重要功能，是生活质量的决定因素。在大脑病变等情况下，可能会发生语言功能中断，病变切除术是一种解决方案。术前计划以确定语言相关的脑区将增加手术后语言保留的机会;然而，规范的语言模板的可用性是必不可少的。患者和方法：在这项研究中，使用了60名年轻人的数据，这些年轻人经过了仔细的心理和身体健康检查，并使用了功能磁共振成像和强大的成像和数据分析方法，用于语言产生的功能性大脑地图，结果：所获得的模板表明语言功能应该被认为是一个脑区网络协作的产物，而不是仅仅考虑少数脑区参与其中。结论：本研究具有重要的临床应用价值，并扩展了我们对语言功能神经解剖学的认识。
Objectives: Language is an important human function, and is a determinant of the quality of life. In conditions such as brain lesions, disruption of the language function may occur, and lesion resection is a solution for that. Presurgical planning to determine the language-related brain areas would enhance the chances of language preservation after the operation; however, availability of a normative language template is essential.Patients and Methods: In this study, using data from 60 young individuals who were meticulously checked for mental and physical health, and using fMRI and robust imaging and data analysis methods, functional brain maps for the language production, perception and semantic Were produced.Results: The obtained templates showed that the language function should be considered as the product of the collaboration of a network of brain regions, instead of considering only few brain areas to be involved in that.Conclusion: This study has important clinical applications, and extends our knowledge on the neuroanatomy of the language function.