A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
复制标题
人类永恒基因的多态性与正常成年人的昼夜偏好无关。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
Emmanuel Mignot
中科院分区：
文献类型：
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作者：
Mario Pedrazzoli;L. Ling;Laurel Finn;L. Kubin;T. Young;D. Katzenberg;Emmanuel Mignot
在一项以人群为基础的睡眠障碍自然史流行病学研究中，研究了人类Timeless基因（Q831R, A2634G）中谷氨酰胺到精氨酸氨基酸的单核苷酸多态性对日常偏好的影响。我们对528名受试者进行了单核苷酸多态性基因分型，并使用Horne-Ostberg问卷确定了早起-晚睡的倾向。我们的研究结果表明，Q831R Timeless对人类的“早睡晚睡”倾向没有影响。
The effect of a single nucleotide polymorphism, a glutamine to arginine amino acid substitution in the human Timeless gene (Q831R, A2634G), on diurnal preferences was studied in a random sample of normal volunteers enrolled in a population-based epidemiology study of the natural history of sleep disorders. We genotyped 528 subjects for this single nucleotide polymorphism and determined morningness-eveningness tendencies using the Horne-Ostberg questionnaire. Our results indicate that Q831R Timeless has no influence on morningness- eveningness tendencies in humans.