Ototoxicity of cisplatin administered to guinea pigs via the round window membrane
Ototoxicity of cisplatin administered to guinea pigs via the round window membrane
复制标题
通过圆窗膜给予豚鼠顺铂的耳毒性。
DOI：
10.2131/jts.37.823
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发表时间：
2012-08-01
影响因子：
2
通讯作者：
Yin, Shankai
中科院分区：
文献类型：
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作者：
Xia, Li;Chen, Zhengnong;Yin, Shankai
耳毒性动物模型是耳鼻咽喉科研究的基本工具。这类模型通常是通过连续注射耳毒性药物或联合使用乙丙酮酸和低剂量耳毒性药物来建立的。通过圆窗膜注射(RWM)是一种允许局部药物进入内耳的方法。在这项研究中，47只豚鼠通过RWM注射不同剂量的顺铂，并对动物的听性脑干反应、毛细胞和螺旋神经节神经元的数据进行了分析。我们的结果表明受试者的耳毒性实验效率高，反应小，提示顺铂经RWM给药是一种有效的耳毒性研究动物模型。
Animal models of ototoxicity represent an elementary tool in otolaryngologic research. Such models are usually created via the consecutive injection of ototoxic drugs or the co-administration of ethacrynic acid and low-dose ototoxic drugs. Injection via the round window membrane (RWM) is one approach that allows for local drug delivery into the inner ear. In this study, 47 guinea pigs received an injection of varying doses of cisplatin via the RWM, and data concerning the animals' auditory brainstem responses, hair cells, and spiral ganglion neurons were analyzed. Our results indicate the high efficiency and generally small reaction of the subjects, suggesting that the application of cisplatin via the RWM is an effective animal model for ototoxicity research.